Diacerein
Modify Date: 2024-01-02 11:33:18
Diacerein structure
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Common Name | Diacerein | ||
|---|---|---|---|---|
| CAS Number | 13739-02-1 | Molecular Weight | 368.294 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 631.5±55.0 °C at 760 mmHg | |
| Molecular Formula | C19H12O8 | Melting Point | 217-2180C | |
| MSDS | N/A | Flash Point | 231.8±25.0 °C | |
| Symbol |
GHS07 |
Signal Word | Warning | |
Use of DiacereinDiacerein, a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.Target: IL-1 betaDiacerein, a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases. Diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that play a role in the development of symptoms of degenerative joint diseases such as osteoarthritis. Due to its specific mode of action, which does not involve the inhibition of prostaglandin synthesis, diacerein has been shown to have anti-osteoarthritis and cartilage stimulating properties in vitro and animal models, together with analgesic and anti-inflammatory properties. Due to its excellent gastro-intestinal tolerance, a combination therapy with an analgesic or a NSAID may be recommended during the first 2-4 weeks of treatment. From Wikipedia. |
| Name | 1,8-Diacetoxy-3-carboxyanthraquinone |
|---|---|
| Synonym | More Synonyms |
| Description | Diacerein, a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases.Target: IL-1 betaDiacerein, a interleukin-1 beta inhibitor, is a slow-acting medicine of the class anthraquinone used to treat joint diseases. Diacerein works by blocking the actions of interleukin-1 beta, a protein involved in the inflammation and destruction of cartilage that play a role in the development of symptoms of degenerative joint diseases such as osteoarthritis. Due to its specific mode of action, which does not involve the inhibition of prostaglandin synthesis, diacerein has been shown to have anti-osteoarthritis and cartilage stimulating properties in vitro and animal models, together with analgesic and anti-inflammatory properties. Due to its excellent gastro-intestinal tolerance, a combination therapy with an analgesic or a NSAID may be recommended during the first 2-4 weeks of treatment. From Wikipedia. |
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| Related Catalog | |
| References |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 631.5±55.0 °C at 760 mmHg |
| Melting Point | 217-2180C |
| Molecular Formula | C19H12O8 |
| Molecular Weight | 368.294 |
| Flash Point | 231.8±25.0 °C |
| Exact Mass | 368.053223 |
| PSA | 124.04000 |
| LogP | 1.99 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.634 |
| Storage condition | Refrigerator |
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATAACUTE TOXICITY DATA
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| Symbol |
GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xi |
| Risk Phrases | 36/37/38 |
| Safety Phrases | 26-36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | CB8781000 |
| HS Code | 2918990090 |
| Precursor 8 | |
|---|---|
| DownStream 2 | |
CAS#:478-43-3
CAS#:108-24-7
CAS#:112118-18-0
CAS#:820243-52-5
CAS#:820243-54-7
CAS#:820243-55-8
CAS#:7440-44-0
CAS#:25395-11-3
CAS#:72049-24-2| HS Code | 2918990090 |
|---|---|
| Summary | 2918990090. other carboxylic acids with additional oxygen function and their anhydrides, halides, peroxides and peroxyacids; their halogenated, sulphonated, nitrated or nitrosated derivatives. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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[Diacerein].
Ann. Ital. Med. Int. 1(2) , 172-4, (1986)
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[Efficacy of diacerein on the symptoms and radiographic progression of osteoarthritis].
Presse Med. 31(39 Pt 2) , 4S13-5, (2002) SYMPTOMATIC EFFECTS OF DIACEREIN: Data obtained from several clinical trials have demonstrated that relief of joint pain obtained with the interleukin-1 inhibitor diacerein is comparable with that obs... |
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Diacerein as a disease-modulating agent in osteoarthritis.
Curr. Rheumatol. Rep. 3(6) , 479-83, (2001) This paper reviews the most recent clinical and experimental studies on diacerein, both of which are under investigation. Diacerein could be a disease-modulating agent in osteoarthritis because struct... |
| 4,5-Diacetoxy-9,10-dioxo-9,10-dihydro-2-anthracenecarboxylic acid |
| DIACERHEIN |
| MFCD00468030 |
| DIACETYL RHEIN |
| 2-Anthracenecarboxylic acid, 4,5-bis(acetyloxy)-9,10-dihydro-9,10-dioxo- |
| Fisiodar |
| 4,5-diacetylrhein |
| Rhein Diacetate |
| 4,5-diacetoxy-9,10-dioxo-9,10-dihydroanthracene-2-carboxylic acid |
| SF 277 |
| rhein,diacetate |
| Diacerein |
| 4,5-Bis(acetyloxy)-9,10-dihydro-9,10-dioxo-2-anthracenecarboxylic Acid |
| artrodar |
| Diacereine |
| EINECS 237-310-2 |
| DAR |
| 4,5-Diacetoxyanthraquinone-2-carboxylic Acid |
| diacetylrhein |
- Shanghai Jizhi Biochemical Technology Co., Ltd
- China
- Product Name: Diacerein
- Price: ￥148.0/20mg
- Purity: 98.0%
- Stocking Period: 2 Day
- Contact: Liu jia
- DC Chemicals Limited
- China
- Product Name: 1,8-Diacetoxy-3-carboxyanthraquinone
- Price: $280.0/20mg
- Purity: 98.0%
- Stocking Period: 3 Day
- Contact: Tony Cao
- Zhejiang Hangyu API Co., Ltd
- China
- Product Name: Diacerein
- Price: ￥Inquiry/1kg
- Purity: 99.5%
- Stocking Period: Inquiry
- Contact: Vinnie
- Henan Tianfu Chemical Co., Ltd.
- China
- Product Name: Diacerein API
- Price: $Inquiry/1kg $Inquiry/25kg $Inquiry/1000kg $Inquiry/10ton
- Purity: 99.0%
- Stocking Period: Inquiry
- Contact: Anson
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Price: $79/10mM*1mLinDMSO
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