Thiol-PEG2-acid

Modify Date: 2024-01-29 20:02:34

Thiol-PEG2-acid Structure
Thiol-PEG2-acid structure
Common Name Thiol-PEG2-acid
CAS Number 1379649-73-6 Molecular Weight 194.249
Density 1.2±0.1 g/cm3 Boiling Point 329.0±32.0 °C at 760 mmHg
Molecular Formula C7H14O4S Melting Point N/A
MSDS N/A Flash Point 152.8±25.1 °C

 Use of Thiol-PEG2-acid


Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Thiol-PEG2-acid
Synonym More Synonyms

 Thiol-PEG2-acid Biological Activity

Description Thiol-PEG2-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 329.0±32.0 °C at 760 mmHg
Molecular Formula C7H14O4S
Molecular Weight 194.249
Flash Point 152.8±25.1 °C
Exact Mass 194.061279
LogP 0.06
Vapour Pressure 0.0±1.5 mmHg at 25°C
Index of Refraction 1.485

 Safety Information

Hazard Codes Xi

 Synonyms

3-[2-(2-Sulfanylethoxy)ethoxy]propanoic acid
MFCD24503001
Propanoic acid, 3-[2-(2-mercaptoethoxy)ethoxy]-
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