Bergenin

Modify Date: 2024-01-01 19:17:23

Bergenin Structure
Bergenin structure
 Common Name Bergenin
CAS Number 477-90-7 Molecular Weight 328.271
Density 1.6±0.1 g/cm3 Boiling Point 658.9±55.0 °C at 760 mmHg
Molecular Formula C14H16O9 Melting Point 237-240 °C(lit.)
MSDS Chinese USA Flash Point 250.7±25.0 °C
Symbol GHS07
GHS07		 Signal Word Warning

 Use of Bergenin


Bergenin, a polyphenol, is a potent antinarcotic agent with antioxidant action. IC50 value: < 2.5 μM (antiplasmodial) [3]Target:In vitro: The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% of control group) by administration of bergenin (20 mg/kg) in morphine-treated mice. Furthermore, morphine-induced down-regulation of glutathione (GSH) contents was reversed by bergenin administration in the frontal cortex and liver [2].In vivo: Bergenin attenuated inflammatory cell infiltration and decreased the concentration of NO, TNF-α, IL-1β, and IL-6, which were increased in LPS-induced mouse mastitis [1].

 Names

Name Bengenin
Synonym More Synonyms

 Bergenin Biological Activity

Description Bergenin, a polyphenol, is a potent antinarcotic agent with antioxidant action. IC50 value: < 2.5 μM (antiplasmodial) [3]Target:In vitro: The naloxone-precipitated withdrawal symptom (jumping frequency) was significantly ameliorated (50% of control group) by administration of bergenin (20 mg/kg) in morphine-treated mice. Furthermore, morphine-induced down-regulation of glutathione (GSH) contents was reversed by bergenin administration in the frontal cortex and liver [2].In vivo: Bergenin attenuated inflammatory cell infiltration and decreased the concentration of NO, TNF-α, IL-1β, and IL-6, which were increased in LPS-induced mouse mastitis [1].
Related Catalog
References

[1]. Gao XJ, et al. Bergenin Plays an Anti-Inflammatory Role via the Modulation of MAPK and NF-κB Signaling Pathways in a Mouse Model of LPS-Induced Mastitis. Inflammation. 2015 Jun;38(3):1142-50.

[2]. Yun J, et al. Bergenin decreases the morphine-induced physical dependence via antioxidative activity in mice. Arch Pharm Res. 2015 Jun;38(6):1248-54.

[3]. Uddin G, et al. Comparative antioxidant and antiplasmodial activities of 11-O-galloylbergenin and bergenin isolated from Bergenia ligulata. Trop Biomed. 2014 Mar;31(1):143-8.

 Chemical & Physical Properties

Density 1.6±0.1 g/cm3
Boiling Point 658.9±55.0 °C at 760 mmHg
Melting Point 237-240 °C(lit.)
Molecular Formula C14H16O9
Molecular Weight 328.271
Flash Point 250.7±25.0 °C
Exact Mass 328.079437
PSA 145.91000
LogP 0.05
Vapour Pressure 0.0±2.1 mmHg at 25°C
Index of Refraction 1.655
Storage condition ?20°C

 Safety Information

Symbol GHS07
GHS07
Signal Word Warning
Hazard Statements H315-H319-H335
Precautionary Statements P261-P305 + P351 + P338
Hazard Codes Xi: Irritant;
Risk Phrases R36/37/38
Safety Phrases S26-S36
RIDADR NONH for all modes of transport
WGK Germany 3
RTECS UQ0337200

 Synthetic Route

 Articles36

More Articles
Studies on the chemical constituents and anticancer activity of Saxifraga stolonifera (L) Meeb.

Bioorg. Med. Chem. 16 , 1337-44, (2008)

Saxifraga stolonifera, an evergreen dicotyledon, has been identified as an important resource in Chinese medicine due to its anticancer activity. In the present report, chemical components of S. stolo...

Simultaneous quantification of biomarkers bergenin and menisdaurin in the methanol extract of aerial parts of Flueggea virosa by validated HPTLC densitometric method.

J. Chromatogr. Sci. 53 , 824-9, (2015)

A simple, sensitive high-performance thin-layer chromatography (HPTLC) method was developed for the simultaneous quantification of biomarker bergenin and menisdaurin in the methanol extracts of aerial...

A novel lactone from Tripterospermum chinense.

Yao Xue Xue Bao 47(11) , 1517-20, (2012)

A novel lactone, tripterospermumcins E (1), along with four known compounds, sweroside (2), loganic acid (3), 8-epi-kingiside (4) and bergenin (5), were isolated from the aerial parts of Tripterosperm...

 Synonyms

Vakerin
Ai Cha Su
Bergenitol
Bergenit
Peltophorin
CORYLOPSIN
(+)-Bergenin
3,4,8,10-Tetrahydroxy-2-(hydroxymethyl)-9-methoxy-3,4,4a,10b-tetrahydropyrano[3,2-c]isochromen-6(2H)-one
4-Methoxy-2-[tetrahydro-3,4,5-trihydroxy-6-(hydroxymethyl)pyran-2-yl]-a-resorcylic Acid d-Lactone
Pyrano[3,2-c][2]benzopyran-6(2H)-one, 3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-
3,4,4a,10b-Tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxypyrano[3,2-c][2]benzopyran-6(2H)-one
BERGENIN
Bergenin:Pyrano[3,2-c][2]benzopyran-6(2H)-one,3,4,4a,10b-tetrahydro-3,4,8,10-tetrahydroxy-2-(hydroxymethyl)-9-methoxy-, [2R-(2,3,4,4a, 10b)]-,
CUSCUTIN
Ardisic Acid B
MFCD00133120
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