VU 0463271
Modify Date: 2024-02-29 12:43:36
VU 0463271 structure
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Common Name | VU 0463271 | ||
|---|---|---|---|---|
| CAS Number | 1391737-01-1 | Molecular Weight | 382.502 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 602.5±65.0 °C at 760 mmHg | |
| Molecular Formula | C19H18N4OS2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 318.2±34.3 °C | |
Use of VU 0463271VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM. |
| Name | VU0463271 |
|---|---|
| Synonym | More Synonyms |
| Description | VU0463271 is a potent KCC2 antagonist, with an IC50 of 61 nM. |
|---|---|
| Related Catalog | |
| Target |
IC50: 61 nM (KCC2)[1]. |
| In Vitro | VU0463271 is a potent antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM and >100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity in a larger panel of GPCRs, ion channels and transporters. It is also found rapidly cleared in vitro[1]. |
| In Vivo | VU0463271 is found to be a moderate-to-high clearance compound in rat (CL=57 mL/min/kg) following intravenous administration (1 mg/kg); the low volume of distribution at steady state (Vss 0.4 L/kg), coupled with moderate-to-high clearance produce a relatively short t1/2 (9 min) in vivo[1]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 602.5±65.0 °C at 760 mmHg |
| Molecular Formula | C19H18N4OS2 |
| Molecular Weight | 382.502 |
| Flash Point | 318.2±34.3 °C |
| Exact Mass | 382.092194 |
| LogP | 3.03 |
| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
| Index of Refraction | 1.693 |
| N-Cyclopropyl-N-(4-methyl-1,3-thiazol-2-yl)-2-[(6-phenyl-3-pyridazinyl)sulfanyl]acetamide |
| Acetamide, N-cyclopropyl-N-(4-methyl-2-thiazolyl)-2-[(6-phenyl-3-pyridazinyl)thio]- |