Bromo-PEG4-acid

Modify Date: 2024-02-03 17:45:19

Bromo-PEG4-acid Structure
Bromo-PEG4-acid structure
Common Name Bromo-PEG4-acid
CAS Number 1393330-38-5 Molecular Weight 329.185
Density 1.4±0.1 g/cm3 Boiling Point 426.9±40.0 °C at 760 mmHg
Molecular Formula C11H21BrO6 Melting Point N/A
MSDS N/A Flash Point 212.0±27.3 °C

 Use of Bromo-PEG4-acid


Bromo-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-Bromo-3,6,9,12-tetraoxapentadecan-15-oic acid
Synonym More Synonyms

 Bromo-PEG4-acid Biological Activity

Description Bromo-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 426.9±40.0 °C at 760 mmHg
Molecular Formula C11H21BrO6
Molecular Weight 329.185
Flash Point 212.0±27.3 °C
Exact Mass 328.052155
LogP -0.37
Vapour Pressure 0.0±2.2 mmHg at 25°C
Index of Refraction 1.481

 Safety Information

Hazard Codes Xi

 Synonyms

3,6,9,12-Tetraoxapentadecan-15-oic acid, 1-bromo-
1-Bromo-3,6,9,12-tetraoxapentadecan-15-oic acid
MFCD22574799