1807518-67-7

1807518-67-7 structure

Name: Bromoacetamido-PEG4-acid
Chemical Name: 1-Bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid
CAS Number: 1807518-67-7
Molecular Formula: C₁₃H₂₄BrNO₇
Molecular Weight: 386.236
Catalog: Signaling Pathways Antibody-drug Conjugate ADC Linker
Create Date: 2018-07-07 08:06:42
Modify Date: 2025-08-25 19:34:23
Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].

Name	1-Bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid
Synonyms	1-Bromo-2-oxo-6,9,12,15-tetraoxa-3-azaoctadecan-18-oic acid 6,9,12,15-Tetraoxa-3-azaoctadecan-18-oic acid, 1-bromo-2-oxo- MFCD28950779

Description	Bromoacetamido-PEG4-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. Bromoacetamido-PEG4-acid is also a cleavable 4 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs)[2].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Antibody-drug Conjugate >> ADC Linker Signaling Pathways >> PROTAC >> PROTAC Linker
Target	PEGs Cleavable
In Vitro	PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]. ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[2].
References	[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562. [2]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16(5):315-337.

Hazard Codes	Xi