PP2A Cancerous-IN-1
Modify Date: 2024-01-20 10:33:36
PP2A Cancerous-IN-1 structure
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Common Name | PP2A Cancerous-IN-1 | ||
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| CAS Number | 1403933-79-8 | Molecular Weight | 488.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H24N4O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PP2A Cancerous-IN-1PP2A Cancerous-IN-1 is a strong and potent CIP2A (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities[1]. |
| Name | PP2A Cancerous-IN-1 |
|---|
| Description | PP2A Cancerous-IN-1 is a strong and potent CIP2A (Cancerous inhibitor of PP2A) and p-Akt inhibitor. PP2A Cancerous-IN-1 shows the most potent antiproliferative activities[1]. |
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| Related Catalog | |
| Target |
pAKT |
| In Vitro | PP2A Cancerous-IN-1 (2.5 and 5 μM; 24 hours; SK-Hep-1 cells) reduces CIP2A expression and cell viability with a dose dependent manner and is more potent in its action than erlotinib[1]. PP2A Cancerous-IN-1 (5 μM; 24 hours; SK-Hep-1 cells) induces cell apoptosis[1]. PP2A Cancerous-IN-1 shows CIP2A inhibitory activity, reduces p-Akt level, induces PARP cleavage. PP2A Cancerous-IN-1 exhibits high potency with low IC50 values of 2.8 μM against HCC cells[1]. Cell Viability Assay[1] Cell Line: SK-Hep-1 cells Concentration: 2.5 and 5 μM Incubation Time: 24 hours Result: Reduced cell viability with a dose dependent manner. Western Blot Analysis[1] Cell Line: SK-Hep-1 cells Concentration: 2.5 and 5 μM Incubation Time: 24 hours Result: Reduced CIP2A expression. Apoptosis Analysis[1] Cell Line: SK-Hep-1 cells Concentration: 2.5 and 5 μM Incubation Time: 24 hours Result: Induced cell apoptosis. |
| References |
| Molecular Formula | C30H24N4O3 |
|---|---|
| Molecular Weight | 488.54 |