Amino-PEG5-CH2CO2H

Modify Date: 2024-01-04 13:02:29

Amino-PEG5-CH2CO2H Structure
Amino-PEG5-CH2CO2H structure
Common Name Amino-PEG5-CH2CO2H
CAS Number 141282-35-1 Molecular Weight 295.32900
Density N/A Boiling Point N/A
Molecular Formula C12H25NO7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Amino-PEG5-CH2CO2H


Amino-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name [2-(2-{2-[2-(2-amino-ethoxy)-ethoxy]-ethoxy}-ethoxy)-ethoxy]acetic acid
Synonym More Synonyms

 Amino-PEG5-CH2CO2H Biological Activity

Description Amino-PEG5-CH2COOH is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Molecular Formula C12H25NO7
Molecular Weight 295.32900
Exact Mass 295.16300
PSA 109.47000

 Safety Information

Hazard Codes Xi

 Synonyms

h2n-peg5-ch2cooh
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