Hydroxy-Amino-bis(PEG1-C2-Boc)

Modify Date: 2024-01-02 19:57:52

Hydroxy-Amino-bis(PEG1-C2-Boc) Structure
Hydroxy-Amino-bis(PEG1-C2-Boc) structure
Common Name Hydroxy-Amino-bis(PEG1-C2-Boc)
CAS Number 1415800-34-8 Molecular Weight 405.526
Density 1.1±0.1 g/cm3 Boiling Point 478.7±35.0 °C at 760 mmHg
Molecular Formula C20H39NO7 Melting Point N/A
MSDS N/A Flash Point 243.3±25.9 °C

 Use of Hydroxy-Amino-bis(PEG1-C2-Boc)


Hydroxy-Amino-bis(PEG1-C2-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Hydroxy-Amino-(PEG2-t-butyl ester)2
Synonym More Synonyms

 Hydroxy-Amino-bis(PEG1-C2-Boc) Biological Activity

Description Hydroxy-Amino-bis(PEG1-C2-Boc) is an alkyl/ether-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

Alkyl/ether

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.1±0.1 g/cm3
Boiling Point 478.7±35.0 °C at 760 mmHg
Molecular Formula C20H39NO7
Molecular Weight 405.526
Flash Point 243.3±25.9 °C
Exact Mass 405.272644
LogP 1.02
Vapour Pressure 0.0±2.7 mmHg at 25°C
Index of Refraction 1.470

 Safety Information

Hazard Codes Xi

 Synonyms

2-Methyl-2-propanyl 10-(2-hydroxyethyl)-2,2-dimethyl-4-oxo-3,7,13-trioxa-10-azahexadecan-16-oate
3,7,13-Trioxa-10-azahexadecan-16-oic acid, 10-(2-hydroxyethyl)-2,2-dimethyl-4-oxo-, 1,1-dimethylethyl ester
MFCD28657292
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