Rp-cAMPS sodium salt structure
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Common Name | Rp-cAMPS sodium salt | ||
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CAS Number | 142439-94-9 | Molecular Weight | 367.25 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C10H11N5NaO5PS | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of Rp-cAMPS sodium saltRp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. |
Name | Rp-cAMPS sodium salt |
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Description | Rp-cAMPS sodium salt, a cAMP analog, is a potent, competitive cAMP-induced activation of cAMP-dependent PKA I and II (Kis of 12.5 µM and 4.5 µM, respectively) antagonist. Rp-cAMPS sodium salt is resistant to hydrolysis by phosphodiesterases[1][2][3][4][5][6]. |
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Related Catalog | |
Target |
Ki: 6.05 µM (PKA I) and 9.75 µM (PKA II)[1] |
In Vitro | A membrane-permeable competitive cAMP antagonist (Rp-cAMPS) that blocks PKA activation by binding to the regulatory subunits without dissociating the kinase holoenzyme also inhibits synaptic plasticity but has no effect on normal synaptic transmission[2]. |
In Vivo | Rp-cAMPS (10 μM, 15 min) decreases the monosynaptic EPSCs evoked at the PB-CeLC and BLA-CeLC synapses in slices from arthritic rats but not in control neurons from normal animals. The inhibitory effect of Rp-cAMPS is significant compared to predrug (ACSF) control values obtained in the same neurons[2]. |
References |
Molecular Formula | C10H11N5NaO5PS |
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Molecular Weight | 367.25 |