Rp-8-CPT-cAMPS
Modify Date: 2024-01-02 13:16:52
Rp-8-CPT-cAMPS structure
|
Common Name | Rp-8-CPT-cAMPS | ||
|---|---|---|---|---|
| CAS Number | 129735-01-9 | Molecular Weight | 509.85900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C16H14ClN5NaO5PS2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Rp-8-CPT-cAMPSRp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI[1][2]. |
| Name | 8-(4-Chlorophenylthio)adenosine-3′,5′-cyclic Monophosphorothioate, Rp-isomer sodium salt |
|---|---|
| Synonym | More Synonyms |
| Description | Rp-8-CPT-cAMPS, a cAMP analog, is a potent and competitive antagonist of cAMP-induced activation of cAMP-dependent PKA I and II. Rp-8-CPT-cAMPS preferentially selects site A of RI compares to site A of RII and site B of RII compares to site B of RI[1][2]. |
|---|---|
| Related Catalog | |
| Target |
PKA[1] |
| In Vitro | Rp-8-CPT-cAMPS (100 μM; 15 min) blocks phosphorylation of VASP by 6-Bnz-cAMP and largely reduces VASP phosphorylation by forskolin and fenoterol[2]. Rp-8-CPT-cAMPS (100 μM; 30 min) reduces GTP-loading of Rap1 by both 8-pCPT-2'-O-Me-cAMP and 6-Bnz-cAMP[2]. Rp-8-CPT-cAMPS (100 μM; 30 min) largely diminishes the augmentation of bradykinin-induced IL-8 release by the PKA activator 6-Bnz-cAMP and the Epac activator 8-pCPT-2'-O-Me-cAMP[2]. Rp-8-CPT-cAMPS (10 μM) inhibits the endothelium-dependent and -independent relaxation which induced by Venom in pre-contracted rat mesenteric artery rings[3]. |
| References |
| Molecular Formula | C16H14ClN5NaO5PS2 |
|---|---|
| Molecular Weight | 509.85900 |
| Exact Mass | 508.97600 |
| PSA | 207.80000 |
| LogP | 3.77360 |
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
|
Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP.
Science 265 , 1878, (1994) Repetitive activation of hippocampal mossy fibers evokes a long-term potentiation (LTP) of synaptic responses in pyramidal cells in the CA3 region that is independent of N-methyl-D-aspartate receptor ... |
| Rp-8-CPT-cAMPS |
| sodium,(4aR,6R,7R,7aS)-6-[6-amino-8-(4-chlorophenyl)sulfanylpurin-9-yl]-2-oxido-2-sulfanylidene-4a,6,7,7a-tetrahydro-4H-furo[3,2-d][1,3,2]dioxaphosphinin-7-ol |