Lipid peroxidation inhibitor 1

Modify Date: 2024-01-14 08:16:14

Lipid peroxidation inhibitor 1 structure	Common Name	Lipid peroxidation inhibitor 1
	CAS Number	142873-41-4	Molecular Weight	364.52
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₃₂N₂O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of Lipid peroxidation inhibitor 1

Lipid peroxidation inhibitor 1 is a lipid peroxidation inhibitor with an IC50 of 0.07 μM.

Name	Lipid peroxidation inhibitor 1

Description	Lipid peroxidation inhibitor 1 is a lipid peroxidation inhibitor with an IC50 of 0.07 μM.
Related Catalog	Signaling Pathways >> Others >> Others Research Areas >> Neurological Disease
Target	IC50: 0.07μM (lipid peroxidation)[1]
In Vitro	Among the compounds synthesized, Lipid peroxidation inhibitor 1 (26n) exhibits potent effects in the inhibition of lipid peroxidation, with an IC50 of 0.07 μM[1].
In Vivo	Basic molecules 8a and 27 exhibit significant effects against (methamphetamine) MAP-induced hypermotility. Except in these compounds, a phenyl group adjacent to the methyl group in position 2 at a distance seems to be indispensable (compare compounds 26m, o, p with compounds Lipid peroxidation inhibitor 1 (26n), q, r). Among these compounds, Lipid peroxidation inhibitor 1 which has a phenylpiperidinyl group in position 2 is found to be most effective[1].
Cell Assay	To rat liver microsomes (S-9) (0.3 mg of protein/40 mM Tris-malate buffer (pH 7.4), 2.4 mL) (2.4 mL) is added a mixture (1:1; 0.1 mL) of aqueous FeCl2 solution (0.25 mM) and NADPH (3 mM). After incubation of the homogenate for 1 h at 37 °C, peroxide production is determined by the thiobarbituric acid method. The inhibitory activities on lipid peroxidation are expressed as IC50 values or percent inhibition as compare with the amount of production in the vehicle (DMSO) group[1].
Animal Admin	Five-week old male mice (25 to 35 g) are used. Following a 90 min acclimation period, the test compounds (including Lipid peroxidation inhibitor 1) suspended in 5% gum arabic are injected intraperitoneally in a volume of 20 mL/kg. Thirty minutes after treatment with test compounds, methamphetamine dissolved in saline is injected intraperitoneally at a dose of 1 mg/kg in a volume of 20 mL/kg. Immediately after methamphetamine injection, spontaneous motor activity is monitored for 90 min[1].
References	[1]. Ohkawa S, et al. 5-aminocoumarans: dual inhibitors of lipid peroxidation and dopamine release with protectiveeffects against central nervous system trauma and ischemia. J Med Chem. 1997 Feb 14;40(4):559-73.

Molecular Formula	C₂₄H₃₂N₂O
Molecular Weight	364.52

Hazard Codes	Xi

Shanghai Nianxing Industrial Co., Ltd
China
Product Name: Lipid peroxidation inhibitor 1
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