PKC-theta inhibitor 1

Modify Date: 2024-01-09 14:15:17

PKC-theta inhibitor 1 structure	Common Name	PKC-theta inhibitor 1
	CAS Number	1160501-81-4	Molecular Weight	348.32
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₅F₃N₄O	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of PKC-theta inhibitor 1

PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. PKC-theta inhibitor 1 demonstrates a reduction of symptoms in a mouse model of multiple sclerosis[1].

Name	PKC-theta inhibitor 1

Description	PKC-theta inhibitor 1 is the PKCθ inhibitor with an Ki value of 6 nM, inhibits IL-2 production in vivo with an IC50 of 0.19 μM. PKC-theta inhibitor 1 demonstrates a reduction of symptoms in a mouse model of multiple sclerosis[1].
Related Catalog	Signaling Pathways >> Epigenetics >> PKC Research Areas >> Inflammation/Immunology Signaling Pathways >> TGF-beta/Smad >> PKC
Target	PKCθ:6 nM (Ki) PKCδ:392 μM (Ki) PKCα:1020 μM (Ki) IL-2 production:0.19 μM (IC50)
References	[1]. Collier PN, et al. Discovery of Selective, Orally Bioavailable Pyrazolopyridine Inhibitors of Protein Kinase Cθ (PKCθ) That Ameliorate Symptoms of Experimental Autoimmune Encephalomyelitis. ACS Med Chem Lett. 2019 Jun 27;10(8):1134-1139.

Molecular Formula	C₁₇H₁₅F₃N₄O
Molecular Weight	348.32

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PKC-theta inhibitor 1

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PKC-theta inhibitor 1 Biological Activity

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The content on this webpage is sourced from various professional data sources. If you have any questions or concerns regarding the content, please feel free to contact service1@chemsrc.com.