Biotin-PEG3-Mal

Modify Date: 2024-01-11 22:20:34

Biotin-PEG3-Mal Structure
Biotin-PEG3-Mal structure
Common Name Biotin-PEG3-Mal
CAS Number 1431618-70-0 Molecular Weight 569.671
Density 1.3±0.1 g/cm3 Boiling Point 905.9±65.0 °C at 760 mmHg
Molecular Formula C25H39N5O8S Melting Point N/A
MSDS N/A Flash Point 501.6±34.3 °C

 Use of Biotin-PEG3-Mal


Biotin-PEG3-Mal is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name N-[15-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-13-oxo-3,6,9-trioxa-12-azapentadec-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
Synonym More Synonyms

 Biotin-PEG3-Mal Biological Activity

Description Biotin-PEG3-Mal is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 905.9±65.0 °C at 760 mmHg
Molecular Formula C25H39N5O8S
Molecular Weight 569.671
Flash Point 501.6±34.3 °C
Exact Mass 569.251953
LogP -2.12
Vapour Pressure 0.0±0.3 mmHg at 25°C
Index of Refraction 1.543

 Synonyms

N-[15-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-13-oxo-3,6,9-trioxa-12-azapentadec-1-yl]-5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanamide
1H-Thieno[3,4-d]imidazole-4-pentanamide, N-[15-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-13-oxo-3,6,9-trioxa-12-azapentadec-1-yl]hexahydro-2-oxo-, (3aS,4S,6aR)-
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