Biotin-PEG3-acid

Modify Date: 2024-01-02 18:07:09

Biotin-PEG3-acid Structure
Biotin-PEG3-acid structure
Common Name Biotin-PEG3-acid
CAS Number 252881-76-8 Molecular Weight 447.546
Density 1.2±0.1 g/cm3 Boiling Point 770.7±60.0 °C at 760 mmHg
Molecular Formula C19H33N3O7S Melting Point N/A
MSDS N/A Flash Point 419.9±32.9 °C

 Use of Biotin-PEG3-acid


Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 14-Oxo-18-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10-trioxa-13-azaoctadecan-1-oic acid
Synonym More Synonyms

 Biotin-PEG3-acid Biological Activity

Description Biotin-PEG3-acid is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 770.7±60.0 °C at 760 mmHg
Molecular Formula C19H33N3O7S
Molecular Weight 447.546
Flash Point 419.9±32.9 °C
Exact Mass 447.203918
LogP -1.40
Vapour Pressure 0.0±5.7 mmHg at 25°C
Index of Refraction 1.520
Storage condition 2-8°C

 Safety Information

Hazard Codes Xi

 Synonyms

4,7,10-Trioxa-13-azaoctadecan-1-oic acid, 18-[(3aS,4S,6aR)-hexahydro-2-oxo-1H-thieno[3,4-d]imidazol-4-yl]-14-oxo-
MFCD22574817
14-Oxo-18-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]-4,7,10-trioxa-13-azaoctadecan-1-oic acid
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