p38-α MAPK-IN-5

Modify Date: 2024-01-10 09:47:42

p38-α MAPK-IN-5 structure	Common Name	p38-α MAPK-IN-5
	CAS Number	1443242-46-3	Molecular Weight	679.86
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₃₇H₄₉N₁₁O₂	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of p38-α MAPK-IN-5

p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].

Name	p38-α MAPK-IN-5

Description	p38-α MAPK-IN-5 (compound 4e) is a potent p38α inhibitor with IC50s of 0.1 nM, 0.2 nM, 944 nM, 4100 nM for p38α, p38 β, p38γ, p38δ, respectively. p38-α MAPK-IN-5 has anti-inflammatory effect. p38-α MAPK-IN-5 has the potential for asthma and chronic obstructive pulmonary disease (COPD) research[1].
Related Catalog	Signaling Pathways >> MAPK/ERK Pathway >> p38 MAPK Research Areas >> Inflammation/Immunology
Target	p38α:0.1 nM (IC50) p38β:0.2 nM (IC50) p38γ:944 nM (IC50) p38δ:4100 nM (IC50)
References	[1]. Elisabetta Armani, et al. Design, Synthesis, and Biological Characterization of Inhaled p38α/β MAPK Inhibitors for the Treatment of Lung Inflammatory Diseases. J Med Chem. 2022 May 26;65(10):7170-7192.

Molecular Formula	C₃₇H₄₉N₁₁O₂
Molecular Weight	679.86

p38-α MAPK-IN-5

Use of p38-α MAPK-IN-5

Names

p38-α MAPK-IN-5 Biological Activity

Chemical & Physical Properties