PYRIDINE-2-CARBOXAMIDE

Modify Date: 2024-01-03 18:28:59

PYRIDINE-2-CARBOXAMIDE structure	Common Name	PYRIDINE-2-CARBOXAMIDE
	CAS Number	1452-77-3	Molecular Weight	122.125
	Density	1.2±0.1 g/cm3	Boiling Point	257.7±32.0 °C at 760 mmHg
	Molecular Formula	C₆H₆N₂O	Melting Point	110 °C (dec.)(lit.)
	MSDS	USA	Flash Point	109.7±25.1 °C
	Symbol	GHS07	Signal Word	Warning

Use of PYRIDINE-2-CARBOXAMIDE

Picolinamide (2-Picolinamide) is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[1][3].

Name	picolinamide
Synonym	More Synonyms

Description	Picolinamide (2-Picolinamide) is an inhibitor of Poly(ADP-ribose) synthetase of nuclei from rat pancreatic islet cells[1][3].
Related Catalog	Signaling Pathways >> Epigenetics >> PARP Research Areas >> Metabolic Disease Signaling Pathways >> Cell Cycle/DNA Damage >> PARP
Target	Poly(ADP-ribose) synthetase[1]
In Vitro	Picolinamide (10 μM-1 mM) inhibits Poly(ADP-ribose) synthetase activity[2]. Picolinamide (2 mM) protects against streptozotocin-induced depression of proinsulin synthesis in isolated pancreatic islets of rats[3].
In Vivo	Picolinamide (4 mmol/kg, i.p., rats) inhibits Na+/phosphate cotransport by isolated renal brush border membrane vesicles[1]. Picolinamide (250 mg/kg, i.p., rats) enhances the tumorigenic effect of Streptozotocin and Alloxan on islet B-cells[4]. Animal Model: Rats[1] Dosage: 4 mmol/kg Administration: Intraperitoneal injection (i.p.) Result: Increased renal cortical NAD content (1.5 fold).
References	[1]. Campbell PI, et al. Specific inhibition of rat renal Na+/phosphate cotransport by picolinamide. J Pharmacol Exp Ther. 1989 Oct;251(1):188-92. [2]. Uchigata Y, et al. Protection by superoxide dismutase, catalase, and poly(ADP-ribose) synthetase inhibitors against alloxan- and streptozotocin-induced islet DNA strand breaks and against the inhibition of proinsulin synthesis. J Biol Chem. 1982 Jun 10;257(11):6084-8. [3]. Yamamoto H, et al. Protection by picolinamide, a novel inhibitor of poly (ADP-ribose) synthetase, against both streptozotocin-induced depression of proinsulin synthesis and reduction of NAD content in pancreatic islets. Biochem Biophys Res Commun. 1980 Jul 16;95(1):474-81. [4]. amagami T, et al. Induction of rat pancreatic B-cell tumors by the combined administration of streptozotocin or alloxan and poly(adenosine diphosphate ribose) synthetase inhibitors. Cancer Res. 1985 Apr;45(4):1845-9.

Density	1.2±0.1 g/cm3
Boiling Point	257.7±32.0 °C at 760 mmHg
Melting Point	110 °C (dec.)(lit.)
Molecular Formula	C₆H₆N₂O
Molecular Weight	122.125
Flash Point	109.7±25.1 °C
Exact Mass	122.048012
PSA	55.98000
LogP	-0.24
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.590

PYRIDINE-2-CARBOXAMIDE MSDS(Chinese)

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H315-H319-H335
Precautionary Statements	P261-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi: Irritant;
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
HS Code	2933399090

HS Code	2933399090
Summary	2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

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pyridine-2-carboxamide

Picolinamide

2-Pyridinecarboxamide

2-Pyridinecarboximidic acid

2-PicolinaMide

EINECS 215-921-5

MFCD00023483