Sophocarpine

Modify Date: 2024-01-02 19:11:17

Sophocarpine Structure
Sophocarpine structure
Common Name Sophocarpine
CAS Number 145572-44-7 Molecular Weight 246.348
Density 1.2±0.1 g/cm3 Boiling Point 425.4±45.0 °C at 760 mmHg
Molecular Formula C15H22N2O Melting Point N/A
MSDS N/A Flash Point 194.0±21.1 °C

 Use of Sophocarpine


Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine (monohydrate) has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer[1].

 Names

Name 13,14-Didehydromatridin-15-one
Synonym More Synonyms

 Sophocarpine Biological Activity

Description Sophocarpine (monohydrate) is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine (monohydrate) significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine (monohydrate) has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer[1].
Related Catalog
Target

PI3K

Akt

References

[1]. Huang Y, et al. Sophocarpine inhibits the growth of gastric cancer cells via autophagy and apoptosis. Front Biosci (Landmark Ed). 2019 Mar 1;24:616-627.

 Chemical & Physical Properties

Density 1.2±0.1 g/cm3
Boiling Point 425.4±45.0 °C at 760 mmHg
Molecular Formula C15H22N2O
Molecular Weight 246.348
Flash Point 194.0±21.1 °C
Exact Mass 246.173218
PSA 23.55000
LogP 1.37
Vapour Pressure 0.0±1.0 mmHg at 25°C
Index of Refraction 1.603

 Synonyms

1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, (7aS,13aR,13bR,13cS)-
Sophocarpine
Matridine-13-ene-15-one
Matridin-15-one, 13,14-didehydro-
Matridin-15-one, 13,14-didehydro- (9CI)
13,14-Didehydromatridin-15-one
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