Sophocarpine structure
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Common Name | Sophocarpine | ||
|---|---|---|---|---|
| CAS Number | 6483-15-4 | Molecular Weight | 246.348 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 425.4±45.0 °C at 760 mmHg | |
| Molecular Formula | C15H22N2O | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 194.0±21.1 °C | |
Use of SophocarpineSophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer[1]. |
| Name | Sophocarpine |
|---|---|
| Synonym | More Synonyms |
| Description | Sophocarpine is one of the significant alkaloid extracted from the traditional herb medicine Sophora flavescens which has many pharmacological properties such as anti-virus, anti-tumor, anti-inflammatory. Sophocarpine significantly inhibits the growth of gastric cancer (GC) cells through multiple mechanisms such as induction of autophagy, activation of cell apoptosis and down-regulation of cell survival PI3K/AKT signaling pathway. Sophocarpine has been demonstrated to have anti-tumor activity in various cancer cells, including hepatocellular carcinoma, prostate cancer and colorectal cancer[1]. |
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| Related Catalog | |
| Target |
PI3K Akt |
| References |
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 425.4±45.0 °C at 760 mmHg |
| Molecular Formula | C15H22N2O |
| Molecular Weight | 246.348 |
| Flash Point | 194.0±21.1 °C |
| Exact Mass | 246.173218 |
| PSA | 23.55000 |
| LogP | 1.37 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.603 |
|
~%
Sophocarpine CAS#:6483-15-4 |
| Literature: Tetrahedron Letters, , vol. 55, # 4 p. 950 - 953 |
| Precursor 1 | |
|---|---|
| DownStream 1 | |
| 1H,5H,10H-Dipyrido[2,1-f:3',2',1'-ij][1,6]naphthyridin-10-one, 2,3,6,7,7a,8,13,13a,13b,13c-decahydro-, (7aS,13aR,13bR,13cS)- |
| Sophocarpine |
| Matridine-13-ene-15-one |
| Matridin-15-one, 13,14-didehydro- |
| Matridin-15-one, 13,14-didehydro- (9CI) |
| 13,14-Didehydromatridin-15-one |