Biotin-PEG4-alkyne

Modify Date: 2024-01-21 16:35:57

Biotin-PEG4-alkyne Structure
Biotin-PEG4-alkyne structure
Common Name Biotin-PEG4-alkyne
CAS Number 1458576-00-5 Molecular Weight 457.58
Density N/A Boiling Point N/A
Molecular Formula C21H35N3O6S Melting Point 55-64 °C
MSDS N/A Flash Point N/A

 Use of Biotin-PEG4-alkyne


Biotin-PEG4-alkyne is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Acetylene-PEG4-biotin conjugate

 Biotin-PEG4-alkyne Biological Activity

Description Biotin-PEG4-alkyne is a biotin-labeled, PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. Gadd MS, et al. Structural basis of PROTAC cooperative recognition for selective protein degradation. Nat Chem Biol. 2017 May;13(5):514-521.

 Chemical & Physical Properties

Melting Point 55-64 °C
Molecular Formula C21H35N3O6S
Molecular Weight 457.58
Storage condition -20°C