Sucralose-d6

Modify Date: 2024-01-04 06:13:36

Sucralose-d6 Structure
Sucralose-d6 structure
Common Name Sucralose-d6
CAS Number 1459161-55-7 Molecular Weight 403.67
Density 1.7±0.1 g/cm3 Boiling Point 669.4±55.0 °C at 760 mmHg
Molecular Formula C12H13D6Cl3O8 Melting Point N/A
MSDS N/A Flash Point 358.7±31.5 °C

 Use of Sucralose-d6


Sucralose-d6 is deuterium labeled Sucralose. Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents[1][2].

 Names

Name Sucralose-d6
Synonym More Synonyms

 Sucralose-d6 Biological Activity

Description Sucralose-d6 is deuterium labeled Sucralose. Sucralose (E955; Trichlorosucrose) is a non-nutritive artificial sweetener and sugar substitute. Sucralose can activate a conserved neural fasting response and thereby exerts an appetite-stimulating effect in rodents[1][2].
Related Catalog
In Vitro Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.

[2]. M S, et al. Sucralose administered in feed, beginning prenatally through lifespan, induces hematopoietic neoplasias in male swiss mice. Int J Occup Environ Health. 2016 Jan;22(1):7-17.

[3]. Nabanita Kundu, et al. Sucralose promotes accumulation of reactive oxygen species (ROS) and adipogenesis in mesenchymal stromal cells. Stem Cell Res Ther. 2020 Jun 26;11(1):250.

 Chemical & Physical Properties

Density 1.7±0.1 g/cm3
Boiling Point 669.4±55.0 °C at 760 mmHg
Molecular Formula C12H13D6Cl3O8
Molecular Weight 403.67
Flash Point 358.7±31.5 °C
Exact Mass 402.052216
LogP 0.68
Vapour Pressure 0.0±4.6 mmHg at 25°C
Index of Refraction 1.604

 Synonyms

α-D-Galactopyranoside-C6,C6-d2, 1,6-dichloro-1,6-dideoxy-β-D-fructofuranosyl-1,1,6,6-d4 4-chloro-4-deoxy-
SUCRALOSE-D6
1,6-Dichloro-1,6-dideoxy-β-D-(1,1,6,6-2H4)fructofuranosyl 4-chloro-4-deoxy-α-D-(C6,C6-2H2)galactopyranoside