Pyruvate Carboxylase-IN-2

Modify Date: 2025-08-25 20:44:35

Pyruvate Carboxylase-IN-2 Structure
Pyruvate Carboxylase-IN-2 structure
 Common Name Pyruvate Carboxylase-IN-2
CAS Number 1469730-16-2 Molecular Weight 402.39
Density N/A Boiling Point N/A
Molecular Formula C21H22O8 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Pyruvate Carboxylase-IN-2


Pyruvate Carboxylase-IN-2 (compound 29) is a potent inhibitor of pyruvate carboxylase (PC) with IC50s of 0.065 and 0.097 μM in cell lysate-based and cell-based PC activity, respectively. Pyruvate Carboxylase-IN-2 is a natural analog of erianin. Pyruvate Carboxylase-IN-2 inhibites the enzymatic activity of PC, mediating the anticancer effect in human hepatocellular carcinoma (HCC)[1].

 Names

Name Pyruvate Carboxylase-IN-2

 Pyruvate Carboxylase-IN-2 Biological Activity

Description Pyruvate Carboxylase-IN-2 (compound 29) is a potent inhibitor of pyruvate carboxylase (PC) with IC50s of 0.065 and 0.097 μM in cell lysate-based and cell-based PC activity, respectively. Pyruvate Carboxylase-IN-2 is a natural analog of erianin. Pyruvate Carboxylase-IN-2 inhibites the enzymatic activity of PC, mediating the anticancer effect in human hepatocellular carcinoma (HCC)[1].
Related Catalog
References

[1]. Sheng Y, et al. Identification of Pyruvate Carboxylase as the Cellular Target of Natural Bibenzyls with Potent Anticancer Activity against Hepatocellular Carcinoma via Metabolic Reprogramming. J Med Chem. 2022;65(1):460-484.

 Chemical & Physical Properties

Molecular Formula C21H22O8
Molecular Weight 402.39
InChIKey YLTGYUHWCZSXHG-CMWLGVBASA-N
SMILES COc1cc(OC2OC(CO)C(O)C(O)C2O)cc2ccc3cccc(O)c3c12
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