NMDAR/TRPM4-IN-2
Modify Date: 2024-04-07 08:13:03
NMDAR/TRPM4-IN-2 structure
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Common Name | NMDAR/TRPM4-IN-2 | ||
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| CAS Number | 2243506-33-2 | Molecular Weight | 330.09 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H19BrCl2N2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of NMDAR/TRPM4-IN-2NMDAR/TRPM4-IN-2 (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 shows neuroprotective activity. NMDAR/TRPM4-IN-2 prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. NMDAR/TRPM4-IN-2 protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1]. |
| Name | NMDAR/TRPM4-IN-2 |
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| Description | NMDAR/TRPM4-IN-2 (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 shows neuroprotective activity. NMDAR/TRPM4-IN-2 prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. NMDAR/TRPM4-IN-2 protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1]. |
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| Related Catalog | |
| In Vitro | NMDAR/TRPM4-IN-2 (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner[1]. NMDAR/TRPM4-IN-2 eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs[1]. |
| References |
| Molecular Formula | C11H19BrCl2N2 |
|---|---|
| Molecular Weight | 330.09 |