Bromo-PEG2-THP

Modify Date: 2024-01-10 16:06:31

Bromo-PEG2-THP Structure
Bromo-PEG2-THP structure
Common Name Bromo-PEG2-THP
CAS Number 152065-54-8 Molecular Weight 253.13
Density 1.3±0.1 g/cm3 Boiling Point 314.3±37.0 °C at 760 mmHg
Molecular Formula C9H17BrO3 Melting Point N/A
MSDS N/A Flash Point 126.8±25.0 °C

 Use of Bromo-PEG2-THP


Bromo-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Bromo-PEG2-THP
Synonym More Synonyms

 Bromo-PEG2-THP Biological Activity

Description Bromo-PEG2-THP is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 314.3±37.0 °C at 760 mmHg
Molecular Formula C9H17BrO3
Molecular Weight 253.13
Flash Point 126.8±25.0 °C
Exact Mass 252.036102
LogP 0.95
Appearance of Characters Liquid
Vapour Pressure 0.0±0.6 mmHg at 25°C
Index of Refraction 1.481

 Synonyms

2-[2-(2-Bromoéthoxy)éthoxy]tétrahydro-2H-pyrane
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