Hosenkoside K

Modify Date: 2024-01-06 21:53:53

Hosenkoside K Structure
Hosenkoside K structure
Common Name Hosenkoside K
CAS Number 160896-49-1 Molecular Weight 1141.293
Density 1.5±0.1 g/cm3 Boiling Point N/A
Molecular Formula C54H92O25 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Hosenkoside K


Hosenkoside K is a baccharane glycoside isolated from the seeds of impatiens balsamina.

 Names

Name Hosenkoside K
Synonym More Synonyms

 Hosenkoside K Biological Activity

Description Hosenkoside K is a baccharane glycoside isolated from the seeds of impatiens balsamina.
Related Catalog
In Vivo The mean peak concentrations of hosenkoside K in rats after oral administration of total saponins of Semen Impatientis is 511.11±234.07 ng/mL, occurring at times of 0.46 h. The terminal half-lives of hosenkoside A is 4.96±1.75 h[1].
Animal Admin Male Wistar rats (7 weeks old, 220±20 g, n=6) are fasted for 12 h. Total saponins of Semen Impatientis at a dose of 300 mg (in 10 mL)/kg are orally administered to rats using a gastric gavage tube. The doses of hosenkoside A is12.4 mg/kg for an oral dose of 300 mg/kg total saponins. Blood samples (0.20 mL) are collected from suborbital vein into heparinized tubes before administration (0 min), and 0.08, 0.25, 0.5, 0.75, 1, 1.5, 2, 4, 6, 8, 12 and 24 h after dosing.
References

[1]. Yu X, et al. An LC-MS/MS method for simultaneous determination of hosenkoside A and hosenkoside K from Semen Impatientis in rat plasma and its application to a pharmacokinetic study. Biomed Chromatogr. 2017 Mar;31(3).

 Chemical & Physical Properties

Density 1.5±0.1 g/cm3
Molecular Formula C54H92O25
Molecular Weight 1141.293
Exact Mass 1140.592773
LogP -1.90
Index of Refraction 1.639

 Synonyms

Glucopyranoside
β-D-Glucopyranoside, (1R,2S,4aR,4bR,6'S,6aR,7R,8S,10aR,10bR,12aS)-7-[(β-D-glucopyranosyloxy)methyl]-6'-[(1S)-2-(β-D-glucopyranosyloxy)-1-methylethyl]octadecahydro-1-hydroxy-4a,4b,7,10a-tetram ethylspiro[chrysene-2(1H),3'(4'H)-[2H]pyran]-8-yl 2-O-β-D-glucopyranosyl-
(1R,2S,4aR,4bR,6'S,6aR,7R,8S,10aR,10bR,12aS)-7-[(β-D-Glucopyranosyloxy)methyl]-6'-[(2S)-1-(β-D-glucopyranosyloxy)-2-propanyl]-1-hydroxy-4a,4b,7,10a-tetramethyloctadecahydro-1H,4'H-spiro[chrysene -2,3'-pyran]-8-yl 2-O-β-D-glucopyranosyl-β-D-glucopyranoside
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