Sigma-1 receptor antagonist 2

Modify Date: 2025-08-29 09:23:29

Sigma-1 receptor antagonist 2 Structure
Sigma-1 receptor antagonist 2 structure
Common Name Sigma-1 receptor antagonist 2
CAS Number 1639220-15-7 Molecular Weight 375.89
Density N/A Boiling Point N/A
Molecular Formula C20H26ClN3O2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Sigma-1 receptor antagonist 2


Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively[1].

 Names

Name Sigma-1 receptor antagonist 2

 Sigma-1 receptor antagonist 2 Biological Activity

Description Sigma-1 receptor antagonist 2 is a potent and selective sigma 1 receptor (σ1 R) antagonist with Kis of 3.88 and 1288 nM for σ1 and σ2 receptor, respectively[1].
Target

Ki: 3.88 nM (σ1 receptor), 1288 nM (σ2 receptor)[1]

References

[1]. Lan Y, et al. Synthesis and biological evaluation of novel sigma-1 receptor antagonists based on pyrimidine scaffold as agents for treating neuropathic pain. J Med Chem. 2014 Dec 26;57(24):10404-23.

 Chemical & Physical Properties

Molecular Formula C20H26ClN3O2
Molecular Weight 375.89
InChIKey FAEOHCOAHZFOEX-UHFFFAOYSA-N
SMILES COc1ccc(-c2nc(C)c(Cl)c(OCCCN3CCCCC3)n2)cc1
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