Bromoacetamido-PEG8-acid

Modify Date: 2024-01-09 10:14:14

Bromoacetamido-PEG8-acid Structure
Bromoacetamido-PEG8-acid structure
Common Name Bromoacetamido-PEG8-acid
CAS Number 1698019-89-4 Molecular Weight 562.446
Density 1.3±0.1 g/cm3 Boiling Point 671.3±55.0 °C at 760 mmHg
Molecular Formula C21H40BrNO11 Melting Point N/A
MSDS N/A Flash Point 359.8±31.5 °C

 Use of Bromoacetamido-PEG8-acid


Bromoacetamido-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name Bromoacetamido-PEG8- acid
Synonym More Synonyms

 Bromoacetamido-PEG8-acid Biological Activity

Description Bromoacetamido-PEG8-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Density 1.3±0.1 g/cm3
Boiling Point 671.3±55.0 °C at 760 mmHg
Molecular Formula C21H40BrNO11
Molecular Weight 562.446
Flash Point 359.8±31.5 °C
Exact Mass 561.178467
LogP -2.74
Vapour Pressure 0.0±4.4 mmHg at 25°C
Index of Refraction 1.486

 Synonyms

6,9,12,15,18,21,24,27-Octaoxa-3-azatriacontan-30-oic acid, 1-bromo-2-oxo-
1-Bromo-2-oxo-6,9,12,15,18,21,24,27-octaoxa-3-azatriacontan-30-oic acid
MFCD27635172