H3B-6527

Modify Date: 2024-01-11 09:53:54

H3B-6527 Structure
H3B-6527 structure
Common Name H3B-6527
CAS Number 1702259-66-2 Molecular Weight 629.537
Density 1.4±0.1 g/cm3 Boiling Point 832.1±65.0 °C at 760 mmHg
Molecular Formula C29H34Cl2N8O4 Melting Point N/A
MSDS N/A Flash Point 457.0±34.3 °C

 Use of H3B-6527


H3B-6527 (H3 Biomedicine) is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice.

 Names

Name H3B-6527
Synonym More Synonyms

 H3B-6527 Biological Activity

Description H3B-6527 (H3 Biomedicine) is a highly selective FGFR4 inhibitor with potent antitumour activity in FGF19 amplified cell lines and mice.
Related Catalog
References

[1]. Dimitra Repana et al. Targeting FGF19/FGFR4 Pathway: A Novel Therapeutic Strategy for Hepatocellular Carcinoma. Diseases 2015, 3, 294-305;

 Chemical & Physical Properties

Density 1.4±0.1 g/cm3
Boiling Point 832.1±65.0 °C at 760 mmHg
Molecular Formula C29H34Cl2N8O4
Molecular Weight 629.537
Flash Point 457.0±34.3 °C
Exact Mass 628.208008
LogP 4.76
Vapour Pressure 0.0±3.1 mmHg at 25°C
Index of Refraction 1.665
Storage condition 2-8℃

 Synonyms

2-Propenamide, N-[2-[[6-[[[(2,6-dichloro-3,5-dimethoxyphenyl)amino]carbonyl]methylamino]-4-pyrimidinyl]amino]-5-(4-ethyl-1-piperazinyl)phenyl]-
N-{2-[(6-{[(2,6-Dichloro-3,5-dimethoxyphenyl)carbamoyl](methyl)amino}-4-pyrimidinyl)amino]-5-(4-ethyl-1-piperazinyl)phenyl}acrylamide
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Price: ¥2908/10 mM * 1 mL in DMSO

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