6-epi-Tadalafil

Modify Date: 2024-01-10 11:02:12

6-epi-Tadalafil Structure
6-epi-Tadalafil structure
Common Name 6-epi-Tadalafil
CAS Number 171596-28-4 Molecular Weight 389.40
Density 1.51±0.1 g/cm3 (20 ºC 760 Torr) Boiling Point N/A
Molecular Formula C22H19N3O4 Melting Point 290-292 ºC
MSDS N/A Flash Point N/A

 Use of 6-epi-Tadalafil


cis-ent-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC50 value of 5 nM and has blood pressure lowering activity[1].

 Names

Name cis-Tadalafil
Synonym More Synonyms

 6-epi-Tadalafil Biological Activity

Description cis-ent-Tadalafil (Tadalafil EP Impurity C) is a highly potent PDE5 inhibitor with an IC50 value of 5 nM and has blood pressure lowering activity[1].
Related Catalog
References

[1]. Daugan A, et al. The discovery of tadalafil: a novel and highly selective PDE5 inhibitor. 2: 2,3,6,7,12,12a-hexahydropyrazino[1',2':1,6]pyrido[3,4-b]indole-1,4-dione analogues. J Med Chem. 2003 Oct 9;46(21):4533-42.  

 Chemical & Physical Properties

Density 1.51±0.1 g/cm3 (20 ºC 760 Torr)
Melting Point 290-292 ºC
Molecular Formula C22H19N3O4
Molecular Weight 389.40
Exact Mass 389.13800
PSA 74.87000
LogP 2.08710
Storage condition 2-8°C
Water Solubility Insuluble (8.6E-3 g/L) (25 ºC)

 Synthetic Route

 Synonyms

Tadalafil 6S,12ar diastereomer
epi-tadafil
UNII-MGY23Z94HY
6-epi-Tadalafil
Tadalafil Impurity 11