Bromoacetamide-PEG3-C1-acid

Modify Date: 2024-01-01 21:00:53

Bromoacetamide-PEG3-C1-acid Structure
Bromoacetamide-PEG3-C1-acid structure
Common Name Bromoacetamide-PEG3-C1-acid
CAS Number 173323-22-3 Molecular Weight 328.15700
Density 1.449g/cm3 Boiling Point 539.5ºC at 760mmHg
Molecular Formula C10H18BrNO6 Melting Point N/A
MSDS N/A Flash Point 280.1ºC

 Use of Bromoacetamide-PEG3-C1-acid


Bromoacetamide-PEG3-C1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 2-[2-[2-[2-[(2-bromoacetyl)amino]ethoxy]ethoxy]ethoxy]acetic acid
Synonym More Synonyms

 Bromoacetamide-PEG3-C1-acid Biological Activity

Description Bromoacetamide-PEG3-C1-acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1]
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562.

 Chemical & Physical Properties

Density 1.449g/cm3
Boiling Point 539.5ºC at 760mmHg
Molecular Formula C10H18BrNO6
Molecular Weight 328.15700
Flash Point 280.1ºC
Exact Mass 327.03200
PSA 97.58000
LogP 0.47220
Vapour Pressure 4.51E-13mmHg at 25°C
Index of Refraction 1.499

 Synonyms

14-Bromo-13-oxo-3,6,9-trioxa-12-azatetradecan-1-oic acid
Tatdabo
OR8462
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