HDAC-IN-42
Modify Date: 2024-01-10 23:04:42
HDAC-IN-42 structure
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Common Name | HDAC-IN-42 | ||
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| CAS Number | 2454024-18-9 | Molecular Weight | 381.34 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C20H15NO7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of HDAC-IN-42HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 µM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase[1]. |
| Name | HDAC-IN-42 |
|---|
| Description | HDAC-IN-42 (compound 14f) is a potent and selective HDAC inhibitor with IC50 values of 0.19 and 4.98 µM for HDAC1 and HDAC6, respectively. HDAC-IN-42 shows anticancer and anti-proliferative activity. HDAC-IN-42 induces apoptosis and cell cycle arrest at G2/M phase[1]. |
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| Related Catalog | |
| Target |
HDAC1:0.19 μM (IC50) HDAC6:4.98 μM (IC50) |
| In Vitro | HDAC-IN-42 (compound 14f) shows anti-proliferative activity with C50s of 9.56, 13.32, 10.46, 6.91 µM for MCF-7, HCT-116, HepG2, Hela cells, respectively[1]. HDAC-IN-42 (1, 5, 10 µM; 24 h) reduces the colony formation and increases the expression of histone H3 and α-tubulin in HeLa cells[1]. HDAC-IN-42 (1, 5, 10 µM; 48 h) induces apoptosis and cell cycle arrest at G2/M phase[1]. |
| References |
| Molecular Formula | C20H15NO7 |
|---|---|
| Molecular Weight | 381.34 |