Crotonoside

Modify Date: 2024-01-03 15:37:08

Crotonoside structure	Common Name	Crotonoside
	CAS Number	1818-71-9	Molecular Weight	283.241
	Density	2.3±0.1 g/cm3	Boiling Point	831ºC at 760 mmHg
	Molecular Formula	C₁₀H₁₃N₅O₅	Melting Point	N/A
	MSDS	Chinese USA	Flash Point	456.4ºC

Use of Crotonoside

Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML[1].

Name	2-hydroxyadenosine
Synonym	More Synonyms

Description	Crotonoside is isolated from Chinese medicinal herb, Croton. Crotonoside inhibits FLT3 and HDAC3/6, exhibits selective inhibition in acute myeloid leukemia (AML) cells. Crotonoside could be a promising new lead compound for the treatment of AML[1].
Related Catalog	Research Areas >> Cancer Signaling Pathways >> Protein Tyrosine Kinase/RTK >> FLT3 Signaling Pathways >> Cell Cycle/DNA Damage >> HDAC Signaling Pathways >> Epigenetics >> HDAC
Target	FLT3 HDAC3 HDAC6
In Vitro	Crotonoside (0-200 μM;) selectively inhibits the viability of AML cell line MV4-11, MOLM-13 (with FLT3-ITD mutant) and KG-1 (without FLT3-ITD mutant) in a dose-dependent manner with an IC50 of 11.6 μM, 12.7 μM and 17.2 μM, respectively[1]. Crotonoside (0-100μM; 7 hours) inhibits the phosphorylation of FLT3 Erk1/2, Akt/mTOR and STAT5 is strongly inhibited by crotonoside at higher concentration of 12.5 μM in a concentration-dependent manner[1]. Crotonoside (0-100 μM; 12 hours) exhibits a dose-dependent increase in the percentage of G0/G1 phase and a dose-dependent decrease in the percentage of G2/M and S phases cells[1]. Crotonoside (0-100 μM; 24 hours) leads to concentration-dependent changes in the number of apoptotic MV4-11 cells, results in a dose-dependent decrease in the level of pro-caspase-3 and a dose-dependent increase in the level of the cleaved caspase-3 fragments[1]. Cell Viability Assay[1] Cell Line: AML cell line MV4-11, MOLM-13 and KG-1 cells Concentration: 0-200 μM Incubation Time: 72 hours Result: Inhibited AML cells growth than other cell lines tested. Western Blot Analysis[1] Cell Line: MV4-11 cells Concentration: 0 μM, 12.5 μM, 25 μM, 50 μM Incubation Time: 7 hours Result: Inhibited AML cells growth than other cell lines tested. Cell Cycle Analysis[1] Cell Line: MV4-11 cells Concentration: 0 μM, 12.5 μM, 25 μM, 50 μM Incubation Time: 12 hours Result: Induced cell cycle arrest in G0/G1. Apoptosis Analysis[1] Cell Line: MV4-11 cells Concentration: 0 μM, 12.5 μM, 25 μM, 50 μM Incubation Time: 24 hours Result: Induced MV4-11 cell apoptosis.
In Vivo	Crotonoside(intraperitoneal and intravenous injection; 70 mg/kg, 35 mg/kg; once daily) induces a significant antitumor activity and inhibited xenograft tumor progress as compared to treatment with vehicle[1]. Animal Model: NOD-SCID mice with MV4-11 cells[1] Dosage: 70 mg/kg, 35 mg/kg Administration: Intraperitoneal and intravenous injection; 70 mg/kg, 35 mg/kg; once daily Result: Produced significant AML tumor inhibition rates of 93.5% at 70 mg/kg.
References	[1]. Li YZ,et al. Crotonoside exhibits selective post-inhibition effect in AML cells via inhibition of FLT3 and HDAC3/6. Oncotarget. 2017 Sep 8;8(61):103087-103099.

Density	2.3±0.1 g/cm3
Boiling Point	831ºC at 760 mmHg
Molecular Formula	C₁₀H₁₃N₅O₅
Molecular Weight	283.241
Flash Point	456.4ºC
Exact Mass	283.091675
PSA	159.51000
LogP	-3.42
Vapour Pressure	2.83E-29mmHg at 25°C
Index of Refraction	1.955

Hazard Codes	Xi
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	2934999090

Precursor 9
CAS#:135041-24-6 6-[(4-Methylphe... CAS#:2096-10-8 2-Aminoadenosine CAS#:16321-99-6 2',3',5'-Tri-O-... CAS#:35109-88-7 2-Iodoadenosine
CAS#:6974-32-9 b-D-Ribofuranos... CAS#:3373-53-3 6-Amino-3,7-dih... CAS#:5987-76-8 6-Chloro-2-iodo... CAS#:118-00-3 Guanosine
CAS#:6979-94-8 2',3',5'-Triace...
DownStream 0