PF-06815345
Modify Date: 2024-03-10 19:38:19
PF-06815345 structure
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Common Name | PF-06815345 | ||
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| CAS Number | 1900686-46-5 | Molecular Weight | 598.029 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 775.4±70.0 °C at 760 mmHg | |
| Molecular Formula | C27H29ClFN9O4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 422.7±35.7 °C | |
Use of PF-06815345PF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay; PF-06815345is identified after optimization of the prodrug moiety to maximize intestinal stability achieving liver targeting of the active compound after prodrug turnover by carboxylesterase (CES1). Hypercholesterolemia Phase 1 Discontinued |
| Name | (1S)-1-{5-[4-(4-{(3-Chloro-2-pyridinyl)[(3R)-3-piperidinyl]carbamoyl}-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-1H-tetrazol-1-yl}ethyl ethyl carbonate |
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| Synonym | More Synonyms |
| Description | PF-06815345 (PF 6815345) is a potent prodrug PCSK9 modulator that inhibits PCSK9 secretion in vitro translation assay; PF-06815345is identified after optimization of the prodrug moiety to maximize intestinal stability achieving liver targeting of the active compound after prodrug turnover by carboxylesterase (CES1). Hypercholesterolemia Phase 1 Discontinued |
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| References | References 1. McClure KF, et al. Angew Chem Int Ed Engl. 2017 Dec 18;56(51):16218-16222. 2. Daniel Pettersen, et al. Small molecule modulators of PCSK9-a literature and patent overview. Bioorg Med Chem Lett. 2018 Feb 26. pii: S0960-894X(18)30151-3. View Related Products by Target PCSK9 Hypercholesterolemia |
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 775.4±70.0 °C at 760 mmHg |
| Molecular Formula | C27H29ClFN9O4 |
| Molecular Weight | 598.029 |
| Flash Point | 422.7±35.7 °C |
| Exact Mass | 597.201477 |
| LogP | 2.13 |
| Vapour Pressure | 0.0±2.7 mmHg at 25°C |
| Index of Refraction | 1.686 |
| (1S)-1-{5-[4-(4-{(3-Chloro-2-pyridinyl)[(3R)-3-piperidinyl]carbamoyl}-2-fluorophenyl)-1-methyl-1H-pyrazol-5-yl]-1H-tetrazol-1-yl}ethyl ethyl carbonate |
| Carbonic acid, (1S)-1-[5-[4-[4-[[(3-chloro-2-pyridinyl)-(3R)-3-piperidinylamino]carbonyl]-2-fluorophenyl]-1-methyl-1H-pyrazol-5-yl]-1H-tetrazol-1-yl]ethyl ethyl ester |