YM 976

Modify Date: 2024-01-09 17:02:59

YM 976 Structure
YM 976 structure
Common Name YM 976
CAS Number 191219-80-4 Molecular Weight 313.78100
Density 1.27g/cm3 Boiling Point 485.4ºC at 760mmHg
Molecular Formula C17H16ClN3O Melting Point 132.7-134.0ºC(lit.)
MSDS Chinese USA Flash Point 247.4ºC

 Use of YM 976


YM976 is a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.2 nM. YM976 shows the dissociation of anti-inflammatory activities from emetic effects and inhibits the antigen-induced airway responses[1].

 Names

Name 4-(3-chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2-one
Synonym More Synonyms

 YM 976 Biological Activity

Description YM976 is a phosphodiesterase 4 (PDE4) inhibitor with an IC50 of 2.2 nM. YM976 shows the dissociation of anti-inflammatory activities from emetic effects and inhibits the antigen-induced airway responses[1].
Related Catalog
References

[1]. Hiroshi Moriuchi, et al. Relaxant effect of YM976, a novel phosphodiesterase 4 inhibitor, on bovine tracheal smooth muscle. Eur J Pharmacol. 2003 May 30;470(1-2):57-64.

 Chemical & Physical Properties

Density 1.27g/cm3
Boiling Point 485.4ºC at 760mmHg
Melting Point 132.7-134.0ºC(lit.)
Molecular Formula C17H16ClN3O
Molecular Weight 313.78100
Flash Point 247.4ºC
Exact Mass 313.09800
PSA 47.78000
LogP 3.69420
Vapour Pressure 1.42E-09mmHg at 25°C
Index of Refraction 1.638
Storage condition 2-8°C

 Safety Information

Personal Protective Equipment Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADR NONH for all modes of transport
WGK Germany 3

 Synonyms

YM 976
Tocris-1821
4-(3-Chlorophenyl)-1,7-diethylpyrido[2,3-d]pyrimidin-2(1H)-one