[DPro5] Corticotropin Releasing Factor, human, rat structure
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Common Name | [DPro5] Corticotropin Releasing Factor, human, rat | ||
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CAS Number | 195628-97-8 | Molecular Weight | 4757.45 | |
Density | N/A | Boiling Point | N/A | |
Molecular Formula | C208H344N60O63S2 | Melting Point | N/A | |
MSDS | N/A | Flash Point | N/A |
Use of [DPro5] Corticotropin Releasing Factor, human, rat[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat[1]. |
Name | [DPro5] Corticotropin Releasing Factor, human, rat |
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Description | [DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat[1]. |
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Related Catalog | |
In Vitro | [DPro5] Corticotropin Releasing Factor, human, rat (1 nM; 1 h) diminishes the amplitude of hippocampal population spike and prevents the onset of long-term potentiation (LTP)[2]. |
In Vivo | [DPro5] Corticotropin Releasing Factor, human, rat (0.01-1 μg; i.c.v.; single dose) doesn’t induce the typical anxiogenic effect, but produces a nonspecific suppression of behavior in Sprague-Dowley rats. And [DPro5] Corticotropin Releasing Factor, human, rat also enhances the short-term memory to a maximum degree and prevented the memory loss induced by diazepam[1]. Animal Model: Sprague-Dowley rats[1] Dosage: 0.01-1 μg Administration: Intracerebroventricular injection; single dose Result: Decreased the number of visits into the light box in the dark-light test. |
References |
Molecular Formula | C208H344N60O63S2 |
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Molecular Weight | 4757.45 |