[DPro5] Corticotropin Releasing Factor, human, rat

Modify Date: 2024-04-03 15:15:37

[DPro5] Corticotropin Releasing Factor, human, rat Structure
[DPro5] Corticotropin Releasing Factor, human, rat structure
Common Name [DPro5] Corticotropin Releasing Factor, human, rat
CAS Number 195628-97-8 Molecular Weight 4757.45
Density N/A Boiling Point N/A
Molecular Formula C208H344N60O63S2 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of [DPro5] Corticotropin Releasing Factor, human, rat


[DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat[1].

 Names

Name [DPro5] Corticotropin Releasing Factor, human, rat

  Biological Activity

Description [DPro5] Corticotropin Releasing Factor, human, rat is a selective R2 agonist of corticotropin releasing factor/hormone. Corticotropin releasing factor (CRF) is a hypothalamic hormone, stimulates the release of adrenocorticotropic hormone (ACTH) and of β-endorphin. [DPro5] Corticotropin Releasing Factor, human, rat fails to cause the typical anxiogenic effect, but modulates learning and memory processes in rat[1].
Related Catalog
In Vitro [DPro5] Corticotropin Releasing Factor, human, rat (1 nM; 1 h) diminishes the amplitude of hippocampal population spike and prevents the onset of long-term potentiation (LTP)[2].
In Vivo [DPro5] Corticotropin Releasing Factor, human, rat (0.01-1 μg; i.c.v.; single dose) doesn’t induce the typical anxiogenic effect, but produces a nonspecific suppression of behavior in Sprague-Dowley rats. And [DPro5] Corticotropin Releasing Factor, human, rat also enhances the short-term memory to a maximum degree and prevented the memory loss induced by diazepam[1]. Animal Model: Sprague-Dowley rats[1] Dosage: 0.01-1 μg Administration: Intracerebroventricular injection; single dose Result: Decreased the number of visits into the light box in the dark-light test.
References

[1]. Shabanov PD, et al. [Anxiogenic and mnestic effects of corticoliberin and its analogs introduced into the brain ventriculi of rats]. Eksp Klin Farmakol. 2006 Nov-Dec;69(6):3-8. Russian.

[2]. Rebaudo R, et al. Electrophysiological effects of sustained delivery of CRF and its receptor agonists in hippocampal slices. Brain Res. 2001 Dec 13;922(1):112-7.

 Chemical & Physical Properties

Molecular Formula C208H344N60O63S2
Molecular Weight 4757.45
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