Thalidomide-PEG2-NH2

Modify Date: 2024-01-09 16:24:04

Thalidomide-PEG2-NH2 Structure
Thalidomide-PEG2-NH2 structure
Common Name Thalidomide-PEG2-NH2
CAS Number 1957235-94-7 Molecular Weight 361.35
Density N/A Boiling Point N/A
Molecular Formula C17H19N3O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Thalidomide-PEG2-NH2


Thalidomide-PEG2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

 Names

Name Thalidomide-PEG2-NH2

 Thalidomide-PEG2-NH2 Biological Activity

Description Thalidomide-PEG2-NH2 is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].
Related Catalog
Target

Cereblon

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2].
References

[1]. Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine. Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11.

[2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-996.

 Chemical & Physical Properties

Molecular Formula C17H19N3O6
Molecular Weight 361.35

 Safety Information

Hazard Codes Xi
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