Mal-PEG2-NH2 TFA

Modify Date: 2025-08-25 10:23:22

Mal-PEG2-NH2 TFA Structure
Mal-PEG2-NH2 TFA structure
Common Name Mal-PEG2-NH2 TFA
CAS Number 660843-23-2 Molecular Weight 342.26800
Density N/A Boiling Point N/A
Molecular Formula C12H17F3N2O6 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Mal-PEG2-NH2 TFA


Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

 Names

Name 1-[2-[2-(2-aminoethoxy)ethoxy]ethyl]pyrrole-2,5-dione,2,2,2-trifluoroacetic acid
Synonym More Synonyms

 Mal-PEG2-NH2 TFA Biological Activity

Description Mal-PEG2-NH2 (TFA) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].
Related Catalog
Target

PEGs

In Vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
References

[1]. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

 Chemical & Physical Properties

Molecular Formula C12H17F3N2O6
Molecular Weight 342.26800
Exact Mass 342.10400
PSA 119.16000
LogP 0.17480

 Synthetic Route

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Mal-PEG2-NH2 TFA Structure

Mal-PEG2-NH2 TFA

CAS#:660843-23-2

Literature: Feau, Clementine; Klein, Emmanuel; Dosche, Carsten; Kerth, Paul; Lebeau, Luc Organic and Biomolecular Chemistry, 2009 , vol. 7, # 24 p. 5259 - 5270

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Mal-PEG2-NH2 TFA Structure

Mal-PEG2-NH2 TFA

CAS#:660843-23-2

Literature: Willems, Lianne I.; Verdoes, Martijn; Florea, Bogdan I.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S. ChemBioChem, 2010 , vol. 11, # 12 p. 1769 - 1781

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Mal-PEG2-NH2 TFA Structure

Mal-PEG2-NH2 TFA

CAS#:660843-23-2

Literature: Willems, Lianne I.; Verdoes, Martijn; Florea, Bogdan I.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S. ChemBioChem, 2010 , vol. 11, # 12 p. 1769 - 1781

~%

Mal-PEG2-NH2 TFA Structure

Mal-PEG2-NH2 TFA

CAS#:660843-23-2

Literature: Willems, Lianne I.; Verdoes, Martijn; Florea, Bogdan I.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S. ChemBioChem, 2010 , vol. 11, # 12 p. 1769 - 1781

~%

Mal-PEG2-NH2 TFA Structure

Mal-PEG2-NH2 TFA

CAS#:660843-23-2

Literature: Willems, Lianne I.; Verdoes, Martijn; Florea, Bogdan I.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S. ChemBioChem, 2010 , vol. 11, # 12 p. 1769 - 1781

~%

Mal-PEG2-NH2 TFA Structure

Mal-PEG2-NH2 TFA

CAS#:660843-23-2

Literature: Willems, Lianne I.; Verdoes, Martijn; Florea, Bogdan I.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S. ChemBioChem, 2010 , vol. 11, # 12 p. 1769 - 1781

~%

Mal-PEG2-NH2 TFA Structure

Mal-PEG2-NH2 TFA

CAS#:660843-23-2

Literature: Willems, Lianne I.; Verdoes, Martijn; Florea, Bogdan I.; Van Der Marel, Gijsbert A.; Overkleeft, Herman S. ChemBioChem, 2010 , vol. 11, # 12 p. 1769 - 1781

 Synonyms

O-(2-Aminoethyl)-O inverted exclamation marka-(2-maleimidoethyl)ethylene glycol trifluoroacetate salt
O-(2-aminoethyl)-O'-(2-maleimidoethyl)ethylene glycol trifluoroacetate salt
1-[2-[2-(2-Aminoethoxy)ethoxy]ethyl]-1H-pyrrole-2,5-dione trifluoroacetate salt
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