PHD-1-IN-1
Modify Date: 2024-01-10 11:40:45
PHD-1-IN-1 structure
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Common Name | PHD-1-IN-1 | ||
|---|---|---|---|---|
| CAS Number | 2009343-14-8 | Molecular Weight | 220.23 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C13H8N4 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PHD-1-IN-1PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an “Arg367-out” pocket[1]. |
| Name | PHD-1-IN-1 |
|---|
| Description | PHD-1-IN-1 is an orally active and potent HIF prolylhydroxylase domain-1 (PHD-1) inhibitor with an IC50 of 0.034 μM. PHD-1-IN-1 has a unique monodentate binding interaction with the active site Fe2+ ion and induces the formation of an “Arg367-out” pocket[1]. |
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| Related Catalog | |
| Target |
IC50: 0.034 μM (PHD-1)[1] |
| In Vivo | PHD-1-IN-1 (compound 17; 3 mg/kg of p.o. or 0.5 mg/kg of i.v.) has a Cmax of 0.8 μM, a AUC of 176 ng•h/mL, Kp,uu of 1.11 and B/P of 0.95[1]. Animal Model: Male C57BL6 mice[1] Dosage: 3 mg/kg (p.o.) or 0.5 mg/kg (i.v.) (Pharmacokinetic Analysis) Administration: PO or IV Result: Had a Cmax of 0.8 μM, a AUC of 176 ng•h/mL, Kp,uu of 1.11 and B/P of 0.95. |
| References |
| Molecular Formula | C13H8N4 |
|---|---|
| Molecular Weight | 220.23 |