SHP2 inhibitor 14
Modify Date: 2023-01-15 19:21:16
SHP2 inhibitor 14 structure
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Common Name | SHP2 inhibitor 14 | ||
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| CAS Number | 2055937-44-3 | Molecular Weight | 463.363 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C21H24Cl2N6O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of SHP2 inhibitor 14SHP2 inhibitor 14 is a novel potent, selective, allosteric, orally acitve SHP2 inhibitor with IC50 of 28 nM; inhibits p-ERK in KYSE-520 cells with IC50 of 93 nM, and shows antiproliferation effect with IC50 of 0.167 uM; demonstrates acceptable stability in mouse liver microsomes (Cl = 36.8, uL/min/mg, T1/2 = 60.2 min) and is sufficiently soluble (pH = 6.8 equilibrium solubility = 0.42 mM) to enable PK pharmacokinetic evaluation; modulate MAPK signaling in vivo in mice subcutaneously implanted with the KYSE520 carcinoma cell line. |
| Name | SHP2 inhibitor 14 |
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| Description | SHP2 inhibitor 14 is a novel potent, selective, allosteric, orally acitve SHP2 inhibitor with IC50 of 28 nM; inhibits p-ERK in KYSE-520 cells with IC50 of 93 nM, and shows antiproliferation effect with IC50 of 0.167 uM; demonstrates acceptable stability in mouse liver microsomes (Cl = 36.8, uL/min/mg, T1/2 = 60.2 min) and is sufficiently soluble (pH = 6.8 equilibrium solubility = 0.42 mM) to enable PK pharmacokinetic evaluation; modulate MAPK signaling in vivo in mice subcutaneously implanted with the KYSE520 carcinoma cell line. |
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| References | References 1. Bagdanoff JT, et al. J Med Chem. 2019 Feb 8. doi: 10.1021/acs.jmedchem.8b01725. View Related Products by Target Protein Phosphatase/PTP |
| Molecular Formula | C21H24Cl2N6O2 |
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| Molecular Weight | 463.363 |