PROTAC BRD4 Degrader-13
Modify Date: 2025-11-03 07:36:46
PROTAC BRD4 Degrader-13 structure
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Common Name | PROTAC BRD4 Degrader-13 | ||
|---|---|---|---|---|
| CAS Number | 2417370-71-7 | Molecular Weight | 1492.54 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C68H85F2N11O17P2S2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PROTAC BRD4 Degrader-13PROTAC BRD4 Degrader-13 (compound 9d) is a potent chimeric BRD4 degrader. PROTAC BRD4 Degrader-13 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.025 nM and 6.0 nM, respectively. |
| Name | PROTAC BRD4 Degrader-13 |
|---|
| Description | PROTAC BRD4 Degrader-13 (compound 9d) is a potent chimeric BRD4 degrader. PROTAC BRD4 Degrader-13 can be conjugated with STEAP1 and CLL1 antibodies to degrade the BRD4 protein in PC3 prostate cancer cells, with a DC50 of 0.025 nM and 6.0 nM, respectively. |
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| Molecular Formula | C68H85F2N11O17P2S2 |
|---|---|
| Molecular Weight | 1492.54 |
| InChIKey | SEILIWDWNYTJFI-UOJLPHGUSA-N |
| SMILES | Cc1ncsc1-c1ccc(CNC(=O)C2CC(OP(=O)(O)OP(=O)(O)OCCNC(=O)CCCCCN3C(=O)C=CC3=O)CN2C(=O)C(NC(=O)CCCCCCCCCCNC(=O)c2cc3c(cc2CS(C)(=O)=O)-c2cn(C)c(=O)c4[nH]cc(c24)CN3c2ncc(F)cc2F)C(C)(C)C)cc1 |
| Storage condition | 2-8°C |