TP 064
Modify Date: 2024-01-10 11:58:50
TP 064 structure
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Common Name | TP 064 | ||
|---|---|---|---|---|
| CAS Number | 2080306-20-1 | Molecular Weight | 458.595 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 642.8±55.0 °C at 760 mmHg | |
| Molecular Formula | C28H34N4O2 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 342.5±31.5 °C | |
Use of TP 064TP-064 is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM and Kd of 7.1 nM, shows high selectivity (>100-fold) for PRMT4 over other PRMTs; reduces dimethylation of BAF155 (IC50=340±30 nM) and MED12 (IC50=43±10 nM) in a dose-dependent manner in cell-baed assays; inhibits the proliferation of a subset of multiple myeloma cell lines (NCI-H929, RPMI8226, Cell IC50 of 379 and 886 nM, respectively) with affected cells arrested in G1 phase of the cell cycle, but has no effect on acute myeloid leukemia, colon cancer, or lung cancer cell lines. |
| Name | N-Methyl-N-[(2-{1-[2-(methylamino)ethyl]-4-piperidinyl}-4-pyridinyl)methyl]-3-phenoxybenzamide |
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| Synonym | More Synonyms |
| Description | TP-064 is a potent, selective, and cell-active inhibitor of PRMT4 with IC50 of <10 nM and Kd of 7.1 nM, shows high selectivity (>100-fold) for PRMT4 over other PRMTs; reduces dimethylation of BAF155 (IC50=340±30 nM) and MED12 (IC50=43±10 nM) in a dose-dependent manner in cell-baed assays; inhibits the proliferation of a subset of multiple myeloma cell lines (NCI-H929, RPMI8226, Cell IC50 of 379 and 886 nM, respectively) with affected cells arrested in G1 phase of the cell cycle, but has no effect on acute myeloid leukemia, colon cancer, or lung cancer cell lines. |
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| References | References 1. Nakayama K, et al. Oncotarget. 2018 Apr 6;9(26):18480-18493. View Related Products by Target Histone Methyltransferase (HMTase) |
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 642.8±55.0 °C at 760 mmHg |
| Molecular Formula | C28H34N4O2 |
| Molecular Weight | 458.595 |
| Flash Point | 342.5±31.5 °C |
| Exact Mass | 458.268188 |
| LogP | 2.56 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.588 |
| N-Methyl-N-[(2-{1-[2-(methylamino)ethyl]-4-piperidinyl}-4-pyridinyl)methyl]-3-phenoxybenzamide |
| Benzamide, N-methyl-N-[[2-[1-[2-(methylamino)ethyl]-4-piperidinyl]-4-pyridinyl]methyl]-3-phenoxy- |
- Shanghai Nianxing Industrial Co., Ltd
- China
- Product Name: TP-064
- Price: Negotiable
- Purity: 98.0%
- Delivery: 10 Day
- Contact: Huang
- Email: sales@echemcloud.com
- ShangHai DC Chemicals Co.,Ltd
- China
- Product Name: TP-064
- Price: ￥Inquiry/1g
- Purity: 98.9%
- Delivery: 1 Day
- Contact: Tony Lai
- Email: order@dcchemicals.com
- DC Chemicals Limited
- China
- Product Name: TP-064
- Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
- Purity: 98.0%
- Delivery: 3 Day
- Contact: Tony Cao
- Email: sales@dcchemicals.com
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