PAD2-IN-2
Modify Date: 2024-01-03 16:46:01
PAD2-IN-2 structure
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Common Name | PAD2-IN-2 | ||
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| CAS Number | 2095107-57-4 | Molecular Weight | 466.508 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C24H27FN6O3 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of PAD2-IN-2PAD2-IN-2 is a potent PAD2 inhibitor. PAD2-IN-2 enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM. PAD2-IN-2 inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells. PAD2-IN-2 can be used for the research of cancer[1]. |
| Name | CAY10723 |
|---|---|
| Synonym | More Synonyms |
| Description | PAD2-IN-2 is a potent PAD2 inhibitor. PAD2-IN-2 enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM. PAD2-IN-2 inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells. PAD2-IN-2 can be used for the research of cancer[1]. |
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| Related Catalog | |
| Target |
PAD2 |
| In Vitro | PAD2-IN-2 (compound 37a; 25 μM; HEK293T/PAD2 cells) exhibits good potency with >60% occupancy in target engagement assay[1]. PAD2-IN-2 (0, 1, 5, 10, 25μM ; 72 h) enters the HEK293T/PAD2 cells with an EC50 of 5.9 μM[1]. PAD2-IN-2 (0, 1, 5, 10, 25μM, 3 h) inhibits histone H3 citrullination with an EC50 of 2.1 μM in HEK293/PAD2 cells[1]. |
| In Vivo | PAD2-IN-2 (AMF30a) protects K. pneumonia pneumonia mice from Imipenem-induced mortality increase[2]. |
| References |
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Molecular Formula | C24H27FN6O3 |
| Molecular Weight | 466.508 |
| Exact Mass | 466.212860 |
| LogP | 0.58 |
| Index of Refraction | 1.665 |
| N-[(1S)-4-{[(1Z)-2-Fluoroethanimidoyl]amino}-1-(4-methoxy-1-methyl-1H-benzimidazol-2-yl)butyl]-3-oxo-4-isoindolinecarboxamide |
| CAY10723 |
| 1H-Isoindole-4-carboxamide, N-[(1S)-4-[[(1Z)-2-fluoro-1-iminoethyl]amino]-1-(4-methoxy-1-methyl-1H-benzimidazol-2-yl)butyl]-2,3-dihydro-3-oxo- |