RIP1-IN-22

Modify Date: 2024-01-13 23:00:18

RIP1-IN-22 structure	Common Name	RIP1-IN-22
	CAS Number	2095515-38-9	Molecular Weight	461.90
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₂₄H₂₀ClN₅O₃	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of RIP1-IN-22

RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1].

Name	RIP1 kinase inhibitor 1

Description	RIP1 kinase inhibitor 1 (compound 22) is a highly potent, orally available, and brain-penetrating RIP1 kinase inhibitor (pKi=9.04)[1].
Related Catalog	Signaling Pathways >> Apoptosis >> RIP kinase Research Areas >> Inflammation/Immunology
Target	pKi: 9.04 (RIP1 kinase)[1]
In Vitro	RIP1 kinase inhibitor 1 (compound 22) strongly suppresses necroptotic cell death and phosphorylation of MLKL(pMLKL) in human colorectal adenocarcinoma HT-29 cells (nectoptosis, IC50=2 nM; pMLKL, IC50=1.3 nM) as well as mouse L-cells NCTC 929 (nectoptosis, IC50=15 nM; pMLKL, IC50=2.7 nM)[1].
References	[1]. Yoshikawa M, et al. Discovery of 7-Oxo-2,4,5,7-tetrahydro-6 H-pyrazolo[3,4- c]pyridine Derivatives as Potent, OrallyAvailable, and Brain-Penetrating Receptor Interacting Protein 1 (RIP1) Kinase Inhibitors: Analysis of Structure-Kinetic Relationships. J Med Chem. 2018 Mar 22;61(6):2384-2409.

Molecular Formula	C₂₄H₂₀ClN₅O₃
Molecular Weight	461.90

DC Chemicals Limited
China
Product Name: RIP1-IN-22
Price: $Inquiry/100mg $Inquiry/250mg $Inquiry/1g
Purity: 98.0%
Stocking Period: 3 Day
Contact: Tony Cao

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