MM-589

Modify Date: 2024-01-03 12:29:30

MM-589 Structure
MM-589 structure
 Common Name MM-589
CAS Number 2097887-20-0 Molecular Weight 572.70
Density N/A Boiling Point N/A
Molecular Formula C28H44N8O5 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of MM-589


MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].

 Names

Name MM-589

 MM-589 Biological Activity

Description MM-589 is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1].
Related Catalog
Target

IC50: 0.90 nM (WDR5), 12.7 nM (HMT)[1]

In Vitro MM-589 (0.01-10 µM) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1].
In Vivo MM-589 has excellent microsomal stability in human, mouse, and rat microsomes[1].
References

[1]. Karatas H, et al. Discovery of a Highly Potent, Cell-Permeable Macrocyclic Peptidomimetic (MM-589) Targeting the WD Repeat Domain 5 Protein (WDR5)-Mixed Lineage Leukemia (MLL) Protein-Protein Interaction. J Med Chem. 2017 Jun 22;60(12):4818-4839.

 Chemical & Physical Properties

Molecular Formula C28H44N8O5
Molecular Weight 572.70
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Chemsrc provides MM-589(CAS#:2097887-20-0) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. Articles of MM-589 are included as well.>> amp version: MM-589

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