MM-589 TFA
Modify Date: 2024-01-12 07:57:55
MM-589 TFA structure
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Common Name | MM-589 TFA | ||
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| CAS Number | 2097887-21-1 | Molecular Weight | 686.72 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C30H45F3N8O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MM-589 TFAMM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1]. |
| Name | MM-589 TFA |
|---|
| Description | MM-589 TFA is a potent inhibitor of WD repeat domain 5 (WDR5) and mixed lineage leukemia (MLL) protein-protein interaction. MM-589 binds to WDR5 with an IC50 of 0.90 nM and inhibits the MLL H3K4 methyltransferase activity with an IC50 of 12.7 nM[1]. |
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| Related Catalog | |
| Target |
IC50: 0.90 nM (WDR5), 12.7 nM (HMT)[1] Ki: <1 nM (WDR5)[1] |
| In Vitro | MM-589 (0.01-10 µM, 4 days or 7 days) potently and selectively inhibits cell growth in human leukemia cell lines harboring MLL translocations[1]. Cell Viability Assay[1] Cell Line: MV4-11 and MOLM-13 cells Concentration: 0.01, 0.1, 1, 10 μM Incubation Time: 4 days or 7 days Result: Potently inhibited MV4-11 and MOLM-13 cell growth with IC50s of 0.25 and 0.21 μM, respectively. Had much weaker activity in the inhibition of cell growth of the HL-60 cell line with an IC50 of 8.6 μM. |
| References |
| Molecular Formula | C30H45F3N8O7 |
|---|---|
| Molecular Weight | 686.72 |
| InChIKey | NARXNZHWAWPJIY-LVENEOMWSA-N |
| SMILES | CCC1NC(=O)C(CCCNC(N)=NC)NC(=O)C(C)(NC(=O)C(C)C)CCNC(=O)C(c2ccccc2)NC1=O.O=C(O)C(F)(F)F |