MM-401 TFA
Modify Date: 2024-01-12 13:49:48
MM-401 TFA structure
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Common Name | MM-401 TFA | ||
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| CAS Number | 1442106-11-7 | Molecular Weight | 700.75 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H47F3N8O7 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of MM-401 TFAMM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 µM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, Apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia[1]. |
| Name | MM-401 TFA |
|---|
| Description | MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 µM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, Apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia[1]. |
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| Related Catalog | |
| Target |
Ki: < 1 nM (WDR5); IC50: 0.9 nM (WDR5-MLL1 interaction), 0.32 µM (MLL1)[1]. |
| In Vitro | MM-401 maintains high binding affinity to WDR5 with a Ki value of < 1 nM and disrupts WDR5-MLL1 interaction with an IC50 value of 0.9 nM[1]. MM-401 is able to specifically inhibit MLL1 activity (IC50 value of 0.32µM) by blocking MLL1-WDR5 interaction and thus the complex assembly[1]. MM-401 (20 μM; 48 h) specifically inhibits MLL1-dependent H3K4 methylation in cells[1]. MM-401 induces similar changes in MLL-AF9 transcriptome as the MLL1 deletion[1]. MM-401 (10, 20, 40 μM; 48 h) specifically inhibits growth of MLL leukemia cells by inducing cell cycle arrest, apoptosis[1]. Apoptosis Analysis[1] Cell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells Concentration: 10, 20, 40 μM Incubation Time: 48 h Result: Specifically induced apoptosis of MLL-AF9 cells. Cell Cycle Analysis[1] Cell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells Concentration: 10, 20, 40 μM Incubation Time: 48 h Result: Induced prominent G1/S arrest in MLL-AF9 cells in a concentration dependent manner. RT-PCR[1] Cell Line: MLL-AF9 cells Concentration: 20 μM Incubation Time: 48 h Result: Significantly decreased H3K4me, expression of 5 Hox A genes, especially Hoxa9 and Hoxa10. |
| References |
| Molecular Formula | C31H47F3N8O7 |
|---|---|
| Molecular Weight | 700.75 |