1442106-11-7
1442106-11-7 structure
- Name: MM-401 TFA
- Chemical Name: MM-401 TFA
- CAS Number: 1442106-11-7
- Molecular Formula: C31H47F3N8O7
- Molecular Weight: 700.75
- Catalog: Signaling Pathways Apoptosis Apoptosis
- Create Date: 2023-01-16 07:50:17
- Modify Date: 2024-01-12 13:49:48
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MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 µM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, Apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia[1].
| Name | MM-401 TFA |
|---|
| Description | MM-401 (TFA) is a MLL1 H3K4 methyltransferase inhibitor. MM-401 inhibits MLL1 activity (IC50 = 0.32 µM) by blocking MLL1-WDR5 interaction. MM-401 can induce cell cycle arrest, Apoptosis and differentiation. MM-401 can be used for the research of MLL leukemia[1]. |
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| Related Catalog | |
| Target |
Ki: < 1 nM (WDR5); IC50: 0.9 nM (WDR5-MLL1 interaction), 0.32 µM (MLL1)[1]. |
| In Vitro | MM-401 maintains high binding affinity to WDR5 with a Ki value of < 1 nM and disrupts WDR5-MLL1 interaction with an IC50 value of 0.9 nM[1]. MM-401 is able to specifically inhibit MLL1 activity (IC50 value of 0.32µM) by blocking MLL1-WDR5 interaction and thus the complex assembly[1]. MM-401 (20 μM; 48 h) specifically inhibits MLL1-dependent H3K4 methylation in cells[1]. MM-401 induces similar changes in MLL-AF9 transcriptome as the MLL1 deletion[1]. MM-401 (10, 20, 40 μM; 48 h) specifically inhibits growth of MLL leukemia cells by inducing cell cycle arrest, apoptosis[1]. Apoptosis Analysis[1] Cell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells Concentration: 10, 20, 40 μM Incubation Time: 48 h Result: Specifically induced apoptosis of MLL-AF9 cells. Cell Cycle Analysis[1] Cell Line: Murine MLL-AF9 and Hoxa9/Meis1 cells Concentration: 10, 20, 40 μM Incubation Time: 48 h Result: Induced prominent G1/S arrest in MLL-AF9 cells in a concentration dependent manner. RT-PCR[1] Cell Line: MLL-AF9 cells Concentration: 20 μM Incubation Time: 48 h Result: Significantly decreased H3K4me, expression of 5 Hox A genes, especially Hoxa9 and Hoxa10. |
| References |
| Molecular Formula | C31H47F3N8O7 |
|---|---|
| Molecular Weight | 700.75 |