Decanoyl-RVKR-CMK TFA

Modify Date: 2024-01-06 18:46:59

Decanoyl-RVKR-CMK TFA Structure
Decanoyl-RVKR-CMK TFA structure
Common Name Decanoyl-RVKR-CMK TFA
CAS Number 2098497-25-5 Molecular Weight 858.43
Density N/A Boiling Point N/A
Molecular Formula C36H67ClF3N11O7 Melting Point N/A
MSDS N/A Flash Point N/A

 Use of Decanoyl-RVKR-CMK TFA


Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits over-expressed gp160 processing and HIV-1 replication[1].

 Names

Name Decanoyl-RVKR-CMK TFA

 Decanoyl-RVKR-CMK TFA Biological Activity

Description Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits over-expressed gp160 processing and HIV-1 replication[1].
Related Catalog
In Vitro Decanoyl-RVKR-CMK (DecRVKRcmk) TFA inhibits HIV-2ROD replication by blocking envelope glycoprotein precursor processing in the Jurkat lymphocyte cell[1]. Decanoyl-RVKR-CMK (DecRVKRcmk) TFA blocks regulated secretion of VGF[2]. Cell Viability Assay[1] Cell Line: HeLaCD4 cells infected with recombinant vaccinia viruses at a multiplicity of infection (MOI) of 5 PFU/mL Concentration: 35 and 70 µΜ Incubation Time: 7 days Result: Peptide at 35 µM significantly inhibited ex vivo HIV-1 and HIV-2 replications (70-80% inhibition).
References

[1]. B Bahbouhi, et al. Inhibition of HIV-2(ROD) replication in a lymphoblastoid cell line by the alpha1-antitrypsin Portland variant (alpha1-PDX) and the decRVKRcmk peptide: comparison with HIV-1(LAI). Microbes Infect. 2001 Nov;3(13):1073-84.

[2]. Angelo L Garcia, et al. A prohormone convertase cleavage site within a predicted alpha-helix mediates sorting of the neuronal and endocrine polypeptide VGF into the regulated secretory pathway. J Biol Chem. 2005 Dec 16;280(50):41595-608.

 Chemical & Physical Properties

Molecular Formula C36H67ClF3N11O7
Molecular Weight 858.43