Z-YVAD-FMK
Modify Date: 2024-01-10 11:01:17
Z-YVAD-FMK structure
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Common Name | Z-YVAD-FMK | ||
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| CAS Number | 210344-97-1 | Molecular Weight | 630.66 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C31H39FN4O9 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | N/A | |
Use of Z-YVAD-FMKAA-Z-YVAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor with anti-inflammatory and anti-tumor activities. |
| Name | Z-YVAD-FMK |
|---|
| Description | AA-Z-YVAD-FMK is a cell-permeable, irreversible pan-caspase inhibitor with anti-inflammatory and anti-tumor activities. |
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| Related Catalog | |
| Target |
Caspase |
| In Vitro | Z-YVAD-FMK (100 μM; 24 hours) significantly downregulated the growth inhibition induced by butyrate in Caco-2 cells[1]. Z-YVAD-FMK (20 μM; pre 1 hour; 24 hours) attenuates the apoptotic induction of III-10 on both HepG2 and BEL-7402 cells, the apoptotic rate of -10 on HepG2 cells is reduced by Z-VAD-FMK from 19.88% to 8.34%, while that on BEL-7402 cells is reduced from 17.56% to 11.98%[4]. Z-YVAD-FMK (1-10 μM; 24 hours) shows inhibitory effect in various cells against TNFr- or anti-CD95-induced cell death, exhibits IC50 values of 0.0015 μM (Murine hepatocytes), 0.027 μM (Murine hepatocytes), 4.8 μM (HepG2), 5.8 μM (HepG2), 1.6 μM (Hela) and 1.1 μM (Jurkat), respectively[5]. Cell Viability Assay[1] Cell Line: Caco-2 cells Concentration: 0-100 μM Incubation Time: 24 hours Result: Inhibited Caco-2 cells growth. Apoptosis Analysis[1] Cell Line: BEL-7402 and HepG2 cells Concentration: 20 μM Incubation Time: Pre 1 hour; 24 hours Result: Induced a caspase-dependent apoptosis in cells. |
| In Vivo | Z-VAD-FMK (intraperitoneal injection; 10mg/kg; pre- 30 minutes) significantly delayed preterm delivery at 18 hours, but after 36 hours treatment, non different exists between Z-VAD-FMK-pretreated and control groups[3]. Animal Model: Day 14.5 pregnant CD1 mice[3] Dosage: 10 mg/kg Administration: Intraperitoneal injection; 10mg/kg; pre-30 minutes Result: Prevented HK-GBS-induced preterm delivery. |
| References |
| Molecular Formula | C31H39FN4O9 |
|---|---|
| Molecular Weight | 630.66 |