JNJ-37822681 dihydrochloride

Modify Date: 2024-01-12 18:39:26

JNJ-37822681 dihydrochloride structure	Common Name	JNJ-37822681 dihydrochloride
	CAS Number	2108806-02-4	Molecular Weight	445.26
	Density	N/A	Boiling Point	N/A
	Molecular Formula	C₁₇H₁₉Cl₂F₅N₄	Melting Point	N/A
	MSDS	N/A	Flash Point	N/A

Use of JNJ-37822681 dihydrochloride

JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[1].

Name	JNJ-37822681 dihydrochloride

Description	JNJ-37822681 dihydrochloride is a potent, specific, centrally active, fast-dissociating dopamine D2 receptor antagonist with a moderate binding affinity for the dopamine D2L receptor (Ki =158 nM), which has potential for the treatment of schizophrenia and bipolar disorder[1].
Related Catalog	Signaling Pathways >> GPCR/G Protein >> Dopamine Receptor Signaling Pathways >> Neuronal Signaling >> Dopamine Receptor Research Areas >> Neurological Disease
Target	Ki: 158 nM (dopamine D(2))[1]
References	[1]. Langlois X, et al. Pharmacology of JNJ-37822681, a specific and fast-dissociating D2 antagonist for the treatment of schizophrenia. J Pharmacol Exp Ther. 2012 Jul;342(1):91-105.

Molecular Formula	C₁₇H₁₉Cl₂F₅N₄
Molecular Weight	445.26

JNJ-37822681 dihydrochloride

Use of JNJ-37822681 dihydrochloride

Names

JNJ-37822681 dihydrochloride Biological Activity

Chemical & Physical Properties